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Site-Specific Coval...
Site-Specific Covalent Immobilization of a Racemization Catalyst onto Lipase-containing Beads
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Wieczorek, Birgit (författare)
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- Träff, Annika (författare)
- Stockholms universitet,Institutionen för organisk kemi
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- Krumlinde, Patrik (författare)
- Stockholms universitet,Institutionen för organisk kemi
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visa fler...
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Dijkstra, Harm P. (författare)
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Egmond, Maarten R. (författare)
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van Koten, Gerard (författare)
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- Bäckvall, Jan-Erling (författare)
- Stockholms universitet,Institutionen för organisk kemi
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Klein Gebbink, Robertus J.M. (författare)
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visa färre...
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(creator_code:org_t)
- Engelska.
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- The synthesis and application of the novel heterogeneous bifunctional catalyst CALB-5 as a racemization and resolution catalyst for the dynamic kinetic resolution is described. The semisynthetic ruthenium lipase hybrid CALB-5 was obtained by inhibiting CALB beads with the novel ruthenium phosphonate complex 5 possessing a lipase active site-directed phosphonate group. By partially inhibiting the lipase beads with 5, a bifunctional catalytic system was obtained. Racemization, by the Ru-catalytic site, gave 0% ee after 24 h, and the kinetic resolution, enzymatic acylation by the uninhibited CALB sites, gave 28% conversion of 1-phenylethanol after 3 h with >99% ee of the acetylated product. A dynamic kinetic resolution experiment of (S)-1-phenylethanol with CALB-5 gave the acylated (R)-product in 18% yield and with >99% ee.
Ämnesord
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Nyckelord
- Organic chemistry
- Organisk kemi
- organisk kemi
- Organic Chemistry
Publikations- och innehållstyp
- vet (ämneskategori)
- ovr (ämneskategori)