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Membrane Proteins D...
Membrane Proteins Diffuse as Dynamic Complexes with Lipids
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- Niemela, Perttu S. (författare)
- VTT Technical Research Center of Finland, Espoo, Finland
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- Miettinen, Markus S. (författare)
- VTT Technical Research Center of Finland, Espoo, Finland
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- Monticelli, Luca (författare)
- Aalto University School of Science and Engineering, Finland,INSERM, Paris
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- Hammaren, Henrik (författare)
- Tampere University of Technology.Finland,VTT Technical Research Center of Finland
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- Bjelkmar, Pär, 1980- (författare)
- Theoretical and Computational Biophysics, Department of Theoretical Physics, Royal Institute of Technology,Erik Lindahl,Stockholm University
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- Murtola, Teemu (författare)
- Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm University
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- Lindahl, Erik (författare)
- Theoretical and Computational Biophysics, Department of Theoretical Physics, Royal Institute of Technology,Stockholm University
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- Vattulainen, Ilpo (författare)
- VTT Technical Research Center of Finland, Espoo, Finland
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(creator_code:org_t)
- 2010-05-14
- 2010
- Engelska.
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Ingår i: Journal of the American Chemical Society. - : American Chemical Society. - 0002-7863 .- 1520-5126. ; 132:22, s. 7574-
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- We describe how membrane proteins diffuse laterally in the membrane plane together with the lipids surrounding them. We find a number of intriguing phenomena. The lateral displacements of the protein and the lipids are strongly correlated, as the protein and the neighboring lipids form a dynamical protein-lipid complex, consisting of similar to 50-100 lipids. The diffusion of the lipids in the complex is much slower compared to the rest of the lipids. We also find a strong directional correlation between the movements of the protein and the lipids in its vicinity. The results imply that in crowded membrane environments there are no ""free"" lipids, as they are all influenced by the protein structure and dynamics. Our results indicate that, in studies of cell membranes, protein and lipid dynamics have to be considered together.
Ämnesord
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
- NATURVETENSKAP -- Kemi -- Teoretisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Theoretical Chemistry (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biofysik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biophysics (hsv//eng)
Nyckelord
- Chemistry
- Kemi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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