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Microtubule-depende...
Microtubule-dependent localization of profilin I mRNA to actin polymerization sites in serum-stimulated cells
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- Johnsson, Anna-Karin, 1980- (författare)
- Stockholms universitet,Avdelningen för cellbiologi
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- Karlsson, Roger (författare)
- Stockholms universitet,Avdelningen för cellbiologi
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(creator_code:org_t)
- Elsevier BV, 2010
- 2010
- Engelska.
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Ingår i: European Journal of Cell Biology. - : Elsevier BV. - 0171-9335 .- 1618-1298. ; 89:5, s. 394-401
- Relaterad länk:
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https://urn.kb.se/re...
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visa fler...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Specific localization of messenger RNA (mRNA) appears to be a general mechanism to accumulate certain proteins to subcellular compartments for participation in local processes, thereby maintaining cell polarity under strict spatiotemporal control. Transportation of mRNA with associated protein components (RNP granules) by the actin microfilament or the microtubule systems is one important mechanism to achieve this locally distributed protein production. Here we provide evidence for a microtubule-dependent localization of mRNA encoding the actin regulatory protein profilin to sites in mouse embryonic fibroblasts, which express enhanced actin polymerization.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Actin polymerization
- Profilin
- mRNA localization
- FISH
- microtubules
- Cell biology
- Cellbiologi
- Cell Biology
- cellbiologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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