Sökning: onr:"swepub:oai:DiVA.org:su-59924" >
Enantioselective co...
Enantioselective conjugate silyl additions to α,β-unsaturated aldehydes catalyzed by combination of transition metal and chiral amine catalysts
-
Ibrahem, Ismail (författare)
-
- Santoro, Stefano (författare)
- Stockholms universitet,Institutionen för organisk kemi
-
- Himo, Fahmi (författare)
- Stockholms universitet,Institutionen för organisk kemi
-
visa fler...
-
- Córdova, Armando (författare)
- Stockholms universitet,Institutionen för organisk kemi
-
visa färre...
-
(creator_code:org_t)
- 2011-02-08
- 2011
- Engelska.
-
Ingår i: Advanced Synthesis and Catalysis. - : Wiley. - 1615-4150 .- 1615-4169. ; 353:2+3, s. 245-252
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- We report that transition metal-catalyzed nucleophilic activation can be combined with chiral amine-catalyzed iminium activation as exemplified by the unprecedented enantioselective conjugate addition of a dimethylsilanyl group to α,β-unsaturated aldehydes. These reactions proceed with excellent 1,4-selectivity to afford the corresponding β-silyl aldehyde products 3 in high yields and up to 97:3 er using inexpensive bench stable copper salts and simple chiral amine catalysts. The reaction canalso generate a quaternary stereocenter with goodenantioselectivity. Density functional calculations are performed to elucidate the reaction mechanism and the origin of enantioselectivity.
Ämnesord
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Nyckelord
- asymmetric catalysis
- organocatalysis
- bsilyl aldehydes
- transition metal catalysis
- α
- β-unsaturated aldehydes
- Organic chemistry
- Organisk kemi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas