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Sökning: onr:"swepub:oai:DiVA.org:su-80409" > Work at night and b...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004920naa a2200589 4500
001oai:DiVA.org:su-80409
003SwePub
008120919s2012 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:124927658
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-804092 URI
0247 a https://doi.org/10.5271/sjweh.32822 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1249276582 URI
040 a (SwePub)sud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Bonde, Jens Peter4 aut
2451 0a Work at night and breast cancer - report on evidence-based options for preventive actions
264 c 2012-02-20
264 1b Scandinavian Journal of Work, Environment and Health,c 2012
338 a print2 rdacarrier
500 a AuthorCount:14;
520 a In 2007, the International Agency for Research on Cancer classified shift work involving circadian disruption as probably carcinogenic to humans (group 2A), primarily based on experimental and epidemiologic evidence for breast cancer. In order to examine options for evidence-based preventive actions, 16 researchers in basic, epidemiological and applied sciences convened at a workshop in Copenhagen 26-27 October 2011. This paper summarizes the evidence from epidemiological and experimental studies and presents possible recommendations for prevention of the effects of night work on breast cancer. Among those studies that quantified duration of shift work, there were statistically significant elevations in risk only after about 20 years working night shift. It is unclear from these studies whether or not there is a modest but real elevated risk for shorter durations. Hence, restriction of the total number of years working night shift could be one future preventive recommendation for shift workers. The diurnal secretion of melatonin by the pineal gland with peak in secretory activity during the night is a good biochemical marker of the circadian rhythm. Disruption of the diurnal melatonin secretion pattern can be diminished by restricting the number of consecutive night shifts. Reddish light and reduced light intensity during work at night could potentially help diminish the inhibitory activity of light with strong intensity on the melatonin secretion, but further mechanistic insight is needed before definite recommendations can be made. Earlier or more intensive mammography screening among female night shift worker is not recommended because the harm benefit ratio in this age group may not be beneficial. Preventive effects of melatonin supplementation on breast cancer risk have not been clearly documented, but may be a promising avenue if a lack of side effects can be shown even after long-term ingestion. Women with previous or current breast cancer should be advised not to work night shifts because of strong experimental evidence demonstrating accelerated tumor growth by suppression of melatonin secretion. Work during the night is widespread worldwide. To provide additional evidence-based recommendations on prevention of diseases related to night shift work, large studies on the impact of various shift schedules and type of light on circadian rhythms need to be conducted in real work environments.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskap0 (SwePub)3032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciences0 (SwePub)3032 hsv//eng
653 a circadian rhythm
653 a melatonin
653 a occupational disease
653 a night work
653 a prevention
653 a shift work
7001 a Hansen, Johnni4 aut
7001 a Kolstad, Henrik A.4 aut
7001 a Mikkelsen, Sigurd4 aut
7001 a Olsen, Jorgen H.4 aut
7001 a Blask, David E.4 aut
7001 a Harma, Mikko4 aut
7001 a Kjuus, Helge4 aut
7001 a de Koning, Harry J.4 aut
7001 a Olsen, Jorn4 aut
7001 a Moller, Morten4 aut
7001 a Schernhammer, Eva S.4 aut
7001 a Stevens, Richard G.4 aut
7001 a Åkerstedt, Torbjörnu Karolinska Institutet,Stockholms universitet,Stressforskningsinstitutet,Enheten för biologisk psykologi och behandlingsforskning4 aut0 (Swepub:su)tke
7102 a Stockholms universitetb Stressforskningsinstitutet4 org
7730 t Scandinavian Journal of Work, Environment and Healthd : Scandinavian Journal of Work, Environment and Healthg 38:4, s. 380-390q 38:4<380-390x 0355-3140x 1795-990X
8564 u https://doi.org/10.5271/sjweh.3282y Fulltext
8564 u https://www.sjweh.fi/download.php?abstract_id=3282&file_nro=1
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-80409
8564 8u https://doi.org/10.5271/sjweh.3282
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:124927658

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