Sökning: onr:"swepub:oai:DiVA.org:su-80935" >
Dynamic changes in ...
Dynamic changes in PET amyloid and FDG imaging at different stages of Alzheimer's disease
-
- Kadir, Ahmadul (författare)
- Karolinska Institutet
-
- Almkvist, Ove (författare)
- Karolinska Institutet,Stockholms universitet,Psykologiska institutionen
-
- Forsberg, Anton (författare)
- Karolinska Institutet
-
visa fler...
-
- Wall, Anders (författare)
- Uppsala universitet,Enheten för nuklearmedicin och PET
-
- Engler, Henry (författare)
- Uppsala universitet,Enheten för nuklearmedicin och PET,Uppsala University Hospital
-
- Långström, Bengt (författare)
- Uppsala universitet,Institutionen för biokemi och organisk kemi,Uppsala Universitet
-
- Nordberg, Agneta (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- Elsevier, 2012
- 2012
- Engelska.
-
Ingår i: Neurobiology of Aging. - : Elsevier. - 0197-4580 .- 1558-1497. ; 33:1, s. 198.e1-198.e14
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- In this study 5 patients with mild cognitive impairment (MCI) and 9 Alzheimer’s disease (AD) patients underwent respectively 3- and 5-year follow-up positron emission tomography (PET) studies with N-methyl [11C] 2-(4-methylaminophenyl)-6-hydroxy-benzothiazole (11C-PIB) and 18F-fluorodeoxyglucose (18F-FDG) to understand the time courses in AD disease processes. Significant increase in PIB retention as well as decrease in regional cerebral metabolic rate of glucose (rCMRglc) was observed at group level in the MCI patients while no significant change was observed in cognitive function. At group level the AD patients showed unchanged high PIB retention at 5-year follow-up compared with baseline. At the individual level, increased, stable, and decreased PIB retention were observed while disease progression was reflected in significant decrease in rCMRglc and cognition. In conclusion, after a long-term follow-up with PET, we observed an increase in fibrillar amyloid load in MCI patients followed by more stable level in clinical AD patients. The rCMRglc starts to decline in MCI patients and became more pronounced in clinical stage which related to continuous decline in cognition.
Ämnesord
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- mild cognitive impairment
- Alzheimer's disease
- positron emission tomography
- 11C-PIB
- 18F-FDG
- cognition
- Psychology
- Psykologi
- Psychology
- psykologi
- MEDICINE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas