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Perfluorinated Alky...
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Glynn, Anders
(författare)
Perfluorinated Alkyl Acids in Blood Serum from Primiparous Women in Sweden : Serial Sampling during Pregnancy and Nursing, And Temporal Trends 1996-2010
- Artikel/kapitelEngelska2012
Förlag, utgivningsår, omfång ...
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2012-08-10
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American Chemical Society (ACS),2012
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:su-81572
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-81572URI
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https://doi.org/10.1021/es301168cDOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:125193150URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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AuthorCount:7;
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We investigated temporal trends of blood serum levels of 13 perfluorinated alkyl acids (PFAAs) and perfluorooctane sulfonamide (FOSA) in primiparous women (N = 413) from Uppsala County, Sweden, sampled 3 weeks after delivery 1996-2010. Levels of the short-chain perfluorobutane sulfonate (PFBS) and perfluorohexane sulfonate (PFHxS) increased 11%/y and 8.3%/y, respectively, and levels of the long-chain perfluorononanoate (PFNA) and perfluorodecanoate (PFDA) increased 4.3%/y and 3.8%/y, respectively. Concomitantly, levels of FOSA (22%/y), perfluorooctane sulfonate (PFOS, 8.4%/y), perfluorodecane sulfonate (PFDS, 10%/y), and perfluorooctanoate (PFOA, 3.1%/y) decreased. Thus, one or several sources of exposure to the latter compounds have been reduced or eliminated, whereas exposure to the former compounds has recently increased. We explored if maternal levels of PFOS, PFOA, and PFNA during the early nursing period are representative for the fetal development period, using serial maternal serum samples, including cord blood (N = 19). PFAA levels in maternal serum sampled during pregnancy and the nursing period as well as in cord blood were strongly correlated. Strongest correlations between cord blood levels and maternal levels were observed for maternal serum sampled shortly before or after the delivery (r = 0.70-0.89 for PFOS and PFOA). A similar pattern was observed for PFNA, although the correlations were less strong due to levels close to the method detection limit in cord blood.
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Berger, UrsStockholms universitet,Institutionen för tillämpad miljövetenskap (ITM)(Swepub:su)urber
(författare)
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Bignert, Anders
(författare)
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Ullah, ShahidStockholms universitet,Institutionen för tillämpad miljövetenskap (ITM)(Swepub:su)shul2239
(författare)
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Aune, Marie
(författare)
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Lignell, SannaKarolinska Institutet
(författare)
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Darnerud, Per Ola
(författare)
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Stockholms universitetInstitutionen för tillämpad miljövetenskap (ITM)
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Environmental Science and Technology: American Chemical Society (ACS)46:16, s. 9071-90790013-936X1520-5851
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