Sökning: onr:"swepub:oai:DiVA.org:su-81805" > Reliability of rapi...
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000 | 04774naa a2200613 4500 | |
001 | oai:DiVA.org:su-81805 | |
003 | SwePub | |
008 | 121101s2012 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-818052 URI |
024 | 7 | a https://doi.org/10.1186/1475-2875-11-2112 DOI |
040 | a (SwePub)su | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Minja, Daniel T. R.4 aut |
245 | 1 0 | a Reliability of rapid diagnostic tests in diagnosing pregnancy associated malaria in North Eastern Tanzania |
264 | c 2012-06-21 | |
264 | 1 | b Springer Science and Business Media LLC,c 2012 |
338 | a print2 rdacarrier | |
500 | a AuthorCount:15; | |
520 | a Background: Accurate diagnosis and prompt treatment of pregnancy-associated malaria (PAM) are key aspects in averting adverse pregnancy outcomes. Microscopy is the gold standard in malaria diagnosis, but it has limited detection and availability. When used appropriately, rapid diagnostic tests (RDTs) could be an ideal diagnostic complement to microscopy, due to their ease of use and adequate sensitivity in detecting even sub-microscopic infections. Polymerase chain reaction (PCR) is even more sensitive, but it is mainly used for research purposes. The accuracy and reliability of RDTs in diagnosing PAM was evaluated using microscopy and PCR. Methods: A cohort of pregnant women in north-eastern Tanzania was followed throughout pregnancy for detection of plasmodial infection using venous and placental blood samples evaluated by histidine rich protein 2 (HRP-2) and parasite lactate dehydrogenase (pLDH) based RDTs (Parascreen (TM)) or HRP-2 only (Paracheck Pf (R) and ParaHIT (R) f), microscopy and nested Plasmodium species diagnostic PCR. Results: From a cohort of 924 pregnant women who completed the follow up, complete RDT and microscopy data was available for 5,555 blood samples and of these 442 samples were analysed by PCR. Of the 5,555 blood samples, 49 ((proportion and 95% confidence interval) 0.9% [0.7 - 1.1]) samples were positive by microscopy and 91 (1.6% [1.3-2.0]) by RDT. Forty-six (50.5% [40.5 - 60.6]) and 45 (49.5% [39.4 - 59.5]) of the RDT positive samples were positive and negative by microscopy, respectively, whereas nineteen (42.2% [29.0 - 56.7]) of the microscopy negative, but RDT positive, samples were positive by PCR. Three (0.05% [0.02 - 0.2]) samples were positive by microscopy but negative by RDT. 351 of the 5,461 samples negative by both RDT and microscopy were tested by PCR and found negative. There was no statistically significant difference between the performances of the different RDTs. Conclusions: Microscopy underestimated the real burden of malaria during pregnancy and RDTs performed better than microscopy in diagnosing PAM. In areas where intermittent preventive treatment during pregnancy may be abandoned due to low and decreasing malaria risk and instead replaced with active case management, screening with RDT is likely to identify most infections in pregnant women and out-performs microscopy as a diagnostic tool. | |
650 | 7 | a NATURVETENSKAPx Biologix Immunologi0 (SwePub)106052 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Immunology0 (SwePub)106052 hsv//eng |
653 | a Rapid diagnostic tests (RDTs) | |
653 | a Reliability | |
653 | a Sensitivity | |
653 | a Plasmodium falciparum | |
653 | a Pregnancy-Associated Malaria (PAM) | |
653 | a Microscopy | |
653 | a Polymerase chain reaction (PCR) | |
653 | a Sub-microscopic infections | |
653 | a Pregnancy outcomes | |
653 | a Tanzania | |
700 | 1 | a Schmiegelow, Christentze4 aut |
700 | 1 | a Oesterholt, Mayke4 aut |
700 | 1 | a Magistrado, Pamela A.4 aut |
700 | 1 | a Boström, Stephanieu Stockholms universitet,Avdelningen för immunologi4 aut0 (Swepub:su)stbo7601 |
700 | 1 | a John, Davis4 aut |
700 | 1 | a Pehrson, Caroline4 aut |
700 | 1 | a Andersen, Daniel4 aut |
700 | 1 | a Deloron, Philippe4 aut |
700 | 1 | a Salanti, Ali4 aut |
700 | 1 | a Lemnge, Martha4 aut |
700 | 1 | a Luty, Adrian J. F.4 aut |
700 | 1 | a Alifrangis, Michael4 aut |
700 | 1 | a Theander, Thor4 aut |
700 | 1 | a Lusingu, John P. A.4 aut |
710 | 2 | a Stockholms universitetb Avdelningen för immunologi4 org |
773 | 0 | t Malaria Journald : Springer Science and Business Media LLCg 11, s. 211-q 11<211-x 1475-2875 |
856 | 4 | u https://doi.org/10.1186/1475-2875-11-211y Fulltext |
856 | 4 | u https://malariajournal.biomedcentral.com/track/pdf/10.1186/1475-2875-11-211 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-81805 |
856 | 4 8 | u https://doi.org/10.1186/1475-2875-11-211 |
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