Sökning: onr:"swepub:oai:DiVA.org:su-86295" > Biomarkers of Plasm...
Fältnamn | Indikatorer | Metadata |
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000 | 03736naa a2200469 4500 | |
001 | oai:DiVA.org:su-86295 | |
003 | SwePub | |
008 | 130111s2012 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-862952 URI |
024 | 7 | a https://doi.org/10.1371/journal.pone.00487632 DOI |
040 | a (SwePub)su | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Boström, Stéphanie,d 1985-u Stockholms universitet,Wenner-Grens institut4 aut0 (Swepub:su)stbo7601 |
245 | 1 0 | a Biomarkers of Plasmodium falciparum infection during pregnancy in women living in Northeastern Tanzania |
264 | c 2012-11-14 | |
264 | 1 | b Public Library of Science (PLoS),c 2012 |
338 | a print2 rdacarrier | |
520 | a In pregnant women, Plasmodium falciparum infections are an important cause of maternal morbidity as well as fetal and neonatal mortality. Erythrocytes infected by these malaria-causing parasites accumulate through adhesive interactions in placental intervillous spaces, thus evading detection in peripheral blood smears. Sequestered infected erythrocytes induce inflammation, offering the possibility of detecting inflammatory mediators in peripheral blood that could act as biomarkers of placental infection. In a longitudinal, prospective study in Tanzania, we quantified a range of different cytokines, chemokines and angiogenic factors in peripheral plasma samples, taken on multiple sequential occasions during pregnancy up to and including delivery, from P. falciparum-infected women and matched uninfected controls. The results show that during healthy, uninfected pregnancies the levels of most of the panel of molecules we measured were largely unchanged except at delivery. In women with P. falciparum, however, both comparative and longitudinal assessments consistently showed that the levels of IL-10 and IP-10 increased significantly whilst that of RANTES decreased significantly, regardless of gestational age at the time the infection was detected. ROC curve analysis indicated that a combination of increased IL-10 and IP-10 levels and decreased RANTES levels might be predictive of P. falciparum infections. In conclusion, our data suggest that host biomarkers in peripheral blood may represent useful diagnostic markers of P. falciparum infection during pregnancy, but placental histology results would need to be included to verify these findings. | |
650 | 7 | a NATURVETENSKAPx Biologix Immunologi0 (SwePub)106052 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Immunology0 (SwePub)106052 hsv//eng |
653 | a immunologi | |
653 | a Immunology | |
700 | 1 | a Ibitokou, Samad4 aut |
700 | 1 | a Oesterholt, Mayke4 aut |
700 | 1 | a Schmiegelow, Christentze4 aut |
700 | 1 | a Persson, Jan-Olovu Stockholms universitet,Matematiska institutionen4 aut0 (Swepub:su)japer |
700 | 1 | a Minja, Daniel4 aut |
700 | 1 | a Lusingu, John4 aut |
700 | 1 | a Lemnge, Martha4 aut |
700 | 1 | a Fievet, Nadine4 aut |
700 | 1 | a Deloron, Philippe4 aut |
700 | 1 | a Luty, Adrian J. F.4 aut |
700 | 1 | a Troye-Blomberg, Maritau Stockholms universitet,Wenner-Grens institut4 aut0 (Swepub:su)marita |
710 | 2 | a Stockholms universitetb Wenner-Grens institut4 org |
773 | 0 | t PLOS ONEd : Public Library of Science (PLoS)g 7:11, s. e48763-q 7:11<e48763-x 1932-6203 |
856 | 4 | u https://doi.org/10.1371/journal.pone.0048763y Fulltext |
856 | 4 | u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0048763&type=printable |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-86295 |
856 | 4 8 | u https://doi.org/10.1371/journal.pone.0048763 |
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