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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03546naa a2200433 4500 | |
| 001 | oai:DiVA.org:su-87427 | |
| 003 | SwePub | |
| 008 | 130206s2012 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-874272 URI |
| 024 | 7 | a https://doi.org/10.2174/18765246012050100132 DOI |
| 040 | a (SwePub)su | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Wändell, Per E.4 aut |
| 245 | 1 0 | a Gender Differences Regarding Novel Biomarkers and Metabolic Risk Factors in Metformin Treated Type 2 Diabetic Patients |
| 264 | 1 | b Bentham Science Publishers Ltd.c 2012 |
| 338 | a print2 rdacarrier | |
| 520 | a We aimed to analyze associations between adiponectin, ghrelin and leptin with anthropometric and metabolic markers in men and women with Metformin-treated type 2 diabetes (n=53), recruited from a trial of relaxation therapies. Anthropometrical measures and fasting blood samples were assessed on three occasions: at baseline, and after 10 and 24 weeks: BMI, waist, HbA1c, insulin, glucose, adiponectin, leptin, fasting ghrelin, high sensitivity C-reactive protein (CRP), tumor necrosis factor α (TNF- α) and interleukin 6 (IL-6). HOMA2ir and HOMA2s were calculated from fasting glucose and insulin, and adiponectin/leptin and adiponectin/HOMA2ir ratios were calculated. In men, higher leptin and lower adiponectin/leptin ratio correlated with insulin and insulin resistance, and in women lower ghrelin with insulin and insulin resistance. In multivariate linear regression, higher levels of leptin were associated with insulin resistance among men, but not among women. Among women, insulin resistance was associated with lower adiponectin/leptin ratio and ghrelin. Factor analysis showed that leptin in women was closely related to anthropometric variables, but in men both related to anthropometric and inflammatory variables. Gender differences could indicate different pathophysiologic mechanisms of insulin resistance and type 2 diabetes among men and women, where leptin possibly could be a better marker among men, and ghrelin among women. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
| 653 | a Adiponectin | |
| 653 | a factor analysis | |
| 653 | a leptin | |
| 653 | a ghrelin | |
| 653 | a insulin resistance | |
| 653 | a diabetes | |
| 700 | 1 | a Gigane, Bruna4 aut |
| 700 | 1 | a Nixon Andreasson, Anna,d 1980-u Stockholms universitet,Stressforskningsinstitutet,Karolinska Institutet, Sweden4 aut0 (Swepub:su)anan6088 |
| 700 | 1 | a Carlsson, Axel C.4 aut |
| 710 | 2 | a Stockholms universitetb Stressforskningsinstitutet4 org |
| 773 | 0 | t The Open Diabetes Journald : Bentham Science Publishers Ltd.g 5, s. 13-19q 5<13-19x 1876-5246 |
| 856 | 4 | u https://doi.org/10.2174/1876524601205010013y Fulltext |
| 856 | 4 | u http://benthamopen.com/contents/pdf/TODIAJ/TODIAJ-5-13.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-87427 |
| 856 | 4 8 | u https://doi.org/10.2174/1876524601205010013 |
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