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Reactivated herpes ...
Reactivated herpes simplex infection increases the risk of Alzheimer's disease
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- Lövheim, Hugo (författare)
- Umeå universitet,Geriatrik
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- Gilthorpe, Jonathan (författare)
- Umeå universitet,Klinisk neurovetenskap
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- Adolfsson, Rolf (författare)
- Umeå universitet,Psykiatri
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- Nilsson, Lars-Göran (författare)
- Stockholms universitet,Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Umeå University, Sweden
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- Elgh, Fredrik (författare)
- Umeå universitet,Virologi
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(creator_code:org_t)
- 2014-07-17
- 2015
- Engelska.
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Ingår i: Alzheimer's & Dementia. - : John Wiley & Sons. - 1552-5260 .- 1552-5279. ; 11:6, s. 593-599
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Previous studies have suggested a link between herpes simplex virus (HSV) type 1 and the development of Alzheimer's disease (AD).METHODS: The present analysis included 3432 persons (53.9% women, mean age at inclusion 62.7 ± 14.4 years) with a mean follow-up time of 11.3 years. The number of incident AD cases was 245. Serum samples were analyzed for anti-HSV antibodies (immunoglobulin (Ig)G and IgM) by enzyme-linked immunosorbent assays.RESULTS: The presence of anti-HSV IgG antibodies was not associated with an increased risk for AD, controlled for age and sex (hazard ratio, HR, 0.993, P = .979). However, the presence of anti-HSV IgM at baseline was associated with an increased risk of developing AD (HR 1.959, P = .012).CONCLUSION: Positivity for anti-HSV IgM, a sign of reactivated infection, was found to almost double the risk for AD, whereas the presence of anti-HSV IgG antibodies did not affect the risk.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Alzheimer's disease
- Cohort study
- Dementia
- HSV
- Herpes
- Herpes simplex
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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