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Untargeted Metaboli...
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Drogan, Dagmar
(författare)
Untargeted Metabolic Profiling Identifies Altered Serum Metabolites of Type 2 Diabetes Mellitus in a Prospective, Nested Case Control Study
- Artikel/kapitelEngelska2015
Förlag, utgivningsår, omfång ...
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2015-03-01
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Oxford University Press (OUP),2015
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LIBRIS-ID:oai:DiVA.org:umu-103562
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-103562URI
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https://doi.org/10.1373/clinchem.2014.228965DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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BACKGROUND:Application of metabolite profiling could expand the etiological knowledge of type 2 diabetes mellitus (T2D). However, few prospective studies apply broad untargeted metabolite profiling to reveal the comprehensive metabolic alterations preceding the onset of T2D. METHODS: We applied untargeted metabolite profiling in serum samples obtained from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort comprising 300 individuals who developed T2D after a median follow-up time of 6 years and 300 matched controls. For that purpose, we used ultraperformance LC-MS with a protocol specifically designed for large-scale metabolomics studies with regard to robustness and repeatability. After multivariate classification to select metabolites with the strongest contribution to disease classification, we applied multivariable-adjusted conditional logistic regression to assess the association of these metabolites with T2D.RESULTS: Among several alterations in lipid metabolism, there was an inverse association with T2D for metabolites chemically annotated as lysophosphatidylcholine(dm16:0) and phosphatidylcholine(O-20:0/O-20:0). Hexose sugars were positively associated with T2D, whereas higher concentrations of a sugar alcohol and a deoxyhexose sugar reduced the odds of diabetes by approximately 60% and 70%, respectively. Furthermore, there was suggestive evidence for a positive association of the circulating purine nucleotide isopentenyladenosine-5' -monophosphate with incident T2D.CONCLUSIONS: This study constitutes one of the largest metabolite profiling approaches of T2D biomarkers in a prospective study population. The findings might help generate new hypotheses about diabetes etiology and develop further targeted studies of a smaller number of potentially important metabolites. (C) 2014 American Association for Clinical Chemistry
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Dunn, Warwick B.
(författare)
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Lin, Wanchang
(författare)
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Buijsse, Brian
(författare)
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Schulze, Matthias B.
(författare)
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Langenberg, Claudia
(författare)
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Brown, Marie
(författare)
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Floegel, Anna
(författare)
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Dietrich, Stefan
(författare)
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Rolandsson, OlovUmeå universitet,Allmänmedicin(Swepub:umu)olro0005
(författare)
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Wedge, David C.
(författare)
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Goodacre, Royston
(författare)
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Forouhi, Nita G.
(författare)
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Sharp, Stephen J.
(författare)
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Spranger, Joachim
(författare)
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Wareham, Nick J.
(författare)
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Boeing, Heiner
(författare)
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Umeå universitetAllmänmedicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Clinical Chemistry: Oxford University Press (OUP)61:3, s. 487-4970009-91471530-8561
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Drogan, Dagmar
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Dunn, Warwick B.
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Lin, Wanchang
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Buijsse, Brian
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Schulze, Matthia ...
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Langenberg, Clau ...
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visa fler...
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Brown, Marie
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Floegel, Anna
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Dietrich, Stefan
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Rolandsson, Olov
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Wedge, David C.
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Goodacre, Roysto ...
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Forouhi, Nita G.
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Sharp, Stephen J ...
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Spranger, Joachi ...
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Wareham, Nick J.
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Boeing, Heiner
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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Clinical Chemist ...
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