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Dependence of light...
Dependence of light attenuation and backscattering on collagen concentration and chondrocyte density in agarose scaffolds
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- Puhakka, Pia (författare)
- Department of Applied Physics, University of Eastern Finland, Kuopio, Finland
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- Ylärinne, Janne, 1990- (författare)
- Department of Applied Physics, University of Eastern Finland, Kuopio, Finland,Chondrogenic and Osteogenic Differentiation Group
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- Lammi, Mikko, 1961- (författare)
- Department of Applied Physics, University of Eastern Finland, Kuopio, Finland,Chondrogenic and Osteogenic Differentiation Group
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- Saarakkala, Simo (författare)
- Department of Medical Technology, Institute of Biomedicine, University of Oulu, Oulu, Finland
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- Tiitu, Virpi (författare)
- School of Medicine, Institute of Biomedicine, Anatomy, University of Eastern Finland, Kuopio, Finland
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- Kröger, Heikki (författare)
- Department of Orthopaedics, Traumatology and Hand Surgery, Kuopio University Hospital, Kuopio, Finland
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- Tuomas, Virén (författare)
- Cancer Center, Kuopio University Hospital, Kuopio, Finland
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- Jurvelin, Jukka (författare)
- Department of Applied Physics, University of Eastern Finland, Kuopio, Finland
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- Töyräs, Juha (författare)
- Department of Applied Physics, University of Eastern Finland, Kuopio, Finland
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(creator_code:org_t)
- 2014-10-13
- 2014
- Engelska.
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Ingår i: Physics in Medicine and Biology. - : Institute of Physics Publishing (IOPP). - 0031-9155 .- 1361-6560. ; 59:21, s. 6537-6548
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Optical coherence tomography (OCT) has been applied for high resolution imaging of articular cartilage. However, the contribution of individual structural elements of cartilage on OCT signal has not been thoroughly studied. We hypothesize that both collagen and chondrocytes, essential structural components of cartilage, act as important light scatterers and that variation in their concentrations can be detected by OCT through changes in backscattering and attenuation. To evaluate this hypothesis, we established a controlled model system using agarose scaffolds embedded with variable collagen concentrations and chondrocyte densities. Using OCT, we measured the backscattering coefficient (µb) and total attenuation coefficient (µt) in these scaffolds. Along our hypothesis, light backscattering and attenuation in agarose were dependent on collagen concentration and chondrocyte density. Significant correlations were found between µt and chondrocyte density (ρ = 0.853, p < 0.001) and between µt and collagen concentration (ρ = 0.694, p < 0.001). µb correlated significantly with chondrocyte density (ρ = 0.504, p < 0.001) but not with collagen concentration (ρ = 0.103, p = 0.422) of the scaffold. Thus, quantitation of light backscattering and, especially, attenuation could be valuable when evaluating the integrity of soft tissues, such as articular cartilage with OCT.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- NATURVETENSKAP -- Fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences (hsv//eng)
Nyckelord
- articular cartilage
- chondrocyte
- collagen
- optical coherence tomography
- attenuation
- backscattering
- fysik
- Physics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Puhakka, Pia
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Ylärinne, Janne, ...
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Lammi, Mikko, 19 ...
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Saarakkala, Simo
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Tiitu, Virpi
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Kröger, Heikki
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Tuomas, Virén
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Jurvelin, Jukka
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Töyräs, Juha
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