Sökning: onr:"swepub:oai:DiVA.org:umu-104488" >
Is 5-HTTLPR linked ...
Is 5-HTTLPR linked to the response of selective serotonin reuptake inhibitors in MDD?
-
Illi, Ari (författare)
-
Poutanen, Outi (författare)
-
Setala-Soikkeli, Eija (författare)
-
visa fler...
-
Kampman, Olli (författare)
-
Viikki, Merja (författare)
-
Huhtala, Heini (författare)
-
Mononen, Nina (författare)
-
- Haraldsson, Susann (författare)
- Umeå universitet,Medicinsk och klinisk genetik
-
- Koivisto, Pasi A. (författare)
- Umeå universitet,Medicinsk och klinisk genetik
-
Leinonen, Esa (författare)
-
Lehtimaki, Terho (författare)
-
visa färre...
-
(creator_code:org_t)
- 2010-07-17
- 2011
- Engelska.
-
Ingår i: European Archives of Psychiatry and Clinical Neuroscience. - : Springer Science and Business Media LLC. - 0940-1334 .- 1433-8491. ; 261:2, s. 95-102
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- The role of a functional polymorphism in the transcriptional control region of serotonin transporter gene (5-HTTLPR, SERTPR) has been studied intensively in major depression and in the response to selective serotonin inhibitors (SSRIs) in major depression. The findings have been contradictory, although majority of the studies indicate that the short allele is associated with poor response to SSRIs in major depression. In the present study, we evaluated the association of 5-HTTLPR with treatment response to SSRI medication in Finnish Caucasian MDD patients. A secondary purpose was to study the possible association of this particular polymorphism with major depressive disorder. The aim of the study was to replicate the previous findings in this area. Primary outcomes of the treatment were remission, defined by an exit score of seven or less, and response, defined by a reduction of at least 50% on the MADRS. We had also a control population of 375 healthy blood donors, as a secondary objective was to evaluate the possible association of this particular polymorphism with major depressive disorder. Twenty-nine of the 85 (34.1%) patients reached the remission and 58.8% achieved the predefined response criteria. The l/l genotype of 5-HTTLPR was presented in 51.7% of those patients who achieved remission vs. 25.0% in the non-remitters (P = 0.03). The result remained statistically significant after adjusting for age, gender, medication and MADRS points at the study entry. However, the small sample size limits the reliability of this result.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Serotonin transporter
- 5-HTTLPR
- MDD
- SSRI
- Drug response
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Illi, Ari
-
Poutanen, Outi
-
Setala-Soikkeli, ...
-
Kampman, Olli
-
Viikki, Merja
-
Huhtala, Heini
-
visa fler...
-
Mononen, Nina
-
Haraldsson, Susa ...
-
Koivisto, Pasi A ...
-
Leinonen, Esa
-
Lehtimaki, Terho
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Neurologi
- Artiklar i publikationen
-
European Archive ...
- Av lärosätet
-
Umeå universitet