Sökning: onr:"swepub:oai:DiVA.org:umu-105269" > A prospective study...
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000 | 05256naa a2200901 4500 | |
001 | oai:DiVA.org:umu-105269 | |
003 | SwePub | |
008 | 150622s2015 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:131341745 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1052692 URI |
024 | 7 | a https://doi.org/10.1093/jnci/djv0102 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1313417452 URI |
040 | a (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Aleksandrova, Krasimira4 aut |
245 | 1 0 | a A prospective study of the immune system activation biomarker neopterin and colorectal cancer risk |
264 | c 2015-02-24 | |
264 | 1 | b Oxford University Press,c 2015 |
338 | a print2 rdacarrier | |
520 | a Background: Neopterin may be relevant for colorectal cancer (CRC) development, as a biomarker of cellular immune activity exerting pleiotropic effects on cellular ageing, oxidative stress, and inflammation. So far, the association between prediagnostic neopterin and colon and rectal cancer risk has not been evaluated in human populations. Methods: A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort using data on plasma concentrations of total neopterin (T-N, sum of neopterin and 7,8-dihydroneopterin) in 830 incident CRC case patients (561 colon and 269 rectal) matched within risk sets to 830 control participants. A subsequent replication study used data from the Hordaland Health Study, where 173 CRC case patients have been diagnosed among 6594 healthy participants over 12 years of follow-up. Results: After multivariable adjustment for a priori chosen CRC risk factors, a "U-shaped" association of T-N with CRC was revealed. Compared with the second quintile of the T-N distribution, the relative risks for the first, third, fourth, and fifth quintiles were 2.37 (95% CI = 1.66 to 3.39), 1.24 (95% CI = 0.87 to 1.77), 1.55 (95% CI = 1.08 to 2.22), and 2.31 (95% CI = 1.63 to 3.27), respectively. Replication of these associations within the Hordaland Health Study yielded similar results. No differences have been observed when the associations were explored by colon and rectal cancer site (two-sided P-difference = .87) and after excluding case patients diagnosed within the first four follow-up years. Conclusions: These novel findings provide evidence of the role of both suppressed and activated cell-mediated immunity as reflected by prediagnostic T-N concentrations in the development of CRC. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a Chuang, Shu-Chun4 aut |
700 | 1 | a Boeing, Heiner4 aut |
700 | 1 | a Zuo, Hui4 aut |
700 | 1 | a Tell, Grethe S4 aut |
700 | 1 | a Pischon, Tobias4 aut |
700 | 1 | a Jenab, Mazda4 aut |
700 | 1 | a Bueno-de-Mesquita, Bas4 aut |
700 | 1 | a Vollset, Stein Emil4 aut |
700 | 1 | a Midttun, Øivind4 aut |
700 | 1 | a Ueland, Per Magne4 aut |
700 | 1 | a Fedirko, Veronika4 aut |
700 | 1 | a Johansson, Mattias4 aut |
700 | 1 | a Weiderpass, Elisabeteu Karolinska Institutet4 aut |
700 | 1 | a Severi, Gianluca4 aut |
700 | 1 | a Racine, Antoine4 aut |
700 | 1 | a Boutron-Ruault, Marie-Christine4 aut |
700 | 1 | a Kaaks, Rudolf4 aut |
700 | 1 | a Kühn, Tilman4 aut |
700 | 1 | a Tjønneland, Anne4 aut |
700 | 1 | a Overvad, Kim4 aut |
700 | 1 | a Quirós, J Ramón4 aut |
700 | 1 | a Jakszyn, Paula4 aut |
700 | 1 | a Sánchez, María-José4 aut |
700 | 1 | a Dorronsoro, Miren4 aut |
700 | 1 | a Chirlaque, Maria-Dolores4 aut |
700 | 1 | a Ardanaz, Eva4 aut |
700 | 1 | a Khaw, Kay-Tee4 aut |
700 | 1 | a Wareham, Nicholas J4 aut |
700 | 1 | a Travis, Ruth C4 aut |
700 | 1 | a Trichopoulou, Antonia4 aut |
700 | 1 | a Lagiou, Pagona4 aut |
700 | 1 | a Trichopoulos, Dimitrios4 aut |
700 | 1 | a Palli, Domenico4 aut |
700 | 1 | a Sieri, Sabina4 aut |
700 | 1 | a Tumino, Rosario4 aut |
700 | 1 | a Panico, Salvatore4 aut |
700 | 1 | a May, Anne M4 aut |
700 | 1 | a Palmqvist, Richardu Umeå universitet,Patologi4 aut0 (Swepub:umu)ripa0001 |
700 | 1 | a Ljuslinder, Ingridu Umeå universitet,Onkologi4 aut0 (Swepub:umu)inlj0001 |
700 | 1 | a Kong, So Yeon J4 aut |
700 | 1 | a Freisling, Heinz4 aut |
700 | 1 | a Gunter, Marc J4 aut |
700 | 1 | a Lu, Yunxiau Karolinska Institutet4 aut |
700 | 1 | a Cross, Amanda J4 aut |
700 | 1 | a Riboli, Elio4 aut |
700 | 1 | a Vineis, Paolo4 aut |
700 | 1 | a Midttun, O4 aut |
710 | 2 | a Karolinska Institutetb Patologi4 org |
773 | 0 | t Journal of the National Cancer Instituted : Oxford University Pressg 107:4q 107:4x 0027-8874x 1460-2105 |
856 | 4 | u https://academic.oup.com/jnci/article-pdf/107/4/djv010/17314224/djv010.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-105269 |
856 | 4 8 | u https://doi.org/10.1093/jnci/djv010 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:131341745 |
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