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Amphetamine modulat...
Amphetamine modulates brain signal variability and working memory in younger and older adults
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Garrett, Douglas D. (författare)
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Nagel, Irene E. (författare)
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Preuschhof, Claudia (författare)
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Burzynska, Agnieszka Z. (författare)
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Marchner, Janina (författare)
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Wiegert, Steffen (författare)
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Jungehuelsing, Gerhard J. (författare)
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- Nyberg, Lars (författare)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Institutionen för strålningsvetenskaper,Umeå centrum för funktionell hjärnavbildning (UFBI)
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Villringer, Arno (författare)
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Li, Shu-Chen (författare)
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Heekeren, Hauke R. (författare)
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- Baeckman, Lars (författare)
- Karolinska Institutet
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Lindenberger, Ulman (författare)
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(creator_code:org_t)
- 2015-06
- 2015
- Engelska.
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 112:24, s. 7593-7598
- Relaterad länk:
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https://www.pnas.org...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Better-performing younger adults typically express greater brain signal variability relative to older, poorer performers. Mechanisms for age and performance-graded differences in brain dynamics have, however, not yet been uncovered. Given the age-related decline of the dopamine (DA) system in normal cognitive aging, DA neuromodulation is one plausible mechanism. Hence, agents that boost systemic DA [such as d-amphetamine (AMPH)] may help to restore deficient signal variability levels. Furthermore, despite the standard practice of counterbalancing drug session order (AMPH first vs. placebo first), it remains understudied how AMPH may interact with practice effects, possibly influencing whether DA up-regulation is functional. We examined the effects of AMPH on functional-MRI-based blood oxygen level-dependent (BOLD) signal variability (SDBOLD) in younger and older adults during a working memory task (letter n-back). Older adults expressed lower brain signal variability at placebo, but met or exceeded young adult SDBOLD levels in the presence of AMPH. Drug session order greatly moderated change-change relations between AMPH-driven SDBOLD and reaction time means (RTmean) and SDs (RTSD). Older adults who received AMPH in the first session tended to improve in RTmean and RTSD when SDBOLD was boosted on AMPH, whereas younger and older adults who received AMPH in the second session showed either a performance improvement when SDBOLD decreased (for RTmean) or no effect at all (for RTSD). The present findings support the hypothesis that age differences in brain signal variability reflect aging-induced changes in dopaminergic neuromodulation. The observed interactions among AMPH, age, and session order highlight the state-and practice-dependent neurochemical basis of human brain dynamics.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- brain signal variability
- dopamine
- aging
- working memory
- fMRI
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Garrett, Douglas ...
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Nagel, Irene E.
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Preuschhof, Clau ...
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Burzynska, Agnie ...
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Marchner, Janina
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Wiegert, Steffen
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visa fler...
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Jungehuelsing, G ...
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Nyberg, Lars
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Villringer, Arno
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Li, Shu-Chen
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Heekeren, Hauke ...
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Baeckman, Lars
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Lindenberger, Ul ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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Proceedings of t ...
- Av lärosätet
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Umeå universitet
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Karolinska Institutet