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  • Julkunen, PetroDepartment of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland; Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland (författare)

Biomechanical, biochemical and structural correlations in immature and mature rabbit articular cartilage.

  • Artikel/kapitelEngelska2009

Förlag, utgivningsår, omfång ...

  • Saunders Elsevier,2009
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-106532
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-106532URI
  • https://doi.org/10.1016/j.joca.2009.07.002DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska &language:-1_t

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • OBJECTIVE: The structure and composition of articular cartilage change during development and growth. These changes lead to alterations in the mechanical properties of cartilage. In the present study, biomechanical, biochemical and structural relationships of articular cartilage during growth and maturation of rabbits are investigated.DESIGN: Articular cartilage specimens from the tibial medial plateaus and femoral medial condyles of female New Zealand white rabbits were collected from seven age-groups; 0 days (n=29), 11 days (n=30), 4 weeks (n=30), 6 weeks (n=30), 3 months (n=24), 6 months (n=24) and 18 months (n=19). The samples underwent mechanical testing under creep indentation. From the mechanical response, instantaneous and equilibrium moduli were determined. Biochemical analyses of tissue collagen, hydroxylysylpyridinoline (HP) and pentosidine (PEN) cross-links in full thickness cartilage samples were conducted. Proteoglycans were investigated depth-wise from the tissue sections by measuring the optical density of Safranin-O-stained samples. Furthermore, depth-wise collagen architecture of articular cartilage was analyzed with polarized light microscopy. Finite element analyses of the samples from different age-groups were conducted to reveal tensile and compressive properties of the fibril network and the matrix of articular cartilage, respectively.RESULTS: Tissue thickness decreased from approximately 3 to approximately 0.5mm until the age of 3 months, while the instantaneous modulus increased with age prior to peak at 4-6 weeks. A lower equilibrium modulus was observed before 3-month-age, after which the equilibrium modulus continued to increase. Collagen fibril orientation angle and parallelism index were inversely related to the instantaneous modulus, tensile fibril modulus and tissue thickness. Collagen content and cross-linking were positively related to the equilibrium compressive properties of the tissue.CONCLUSIONS: During maturation, significant modulation of tissue structure, composition and mechanical properties takes place. Importantly, the present study provides insight into the mechanical, chemical and structural interactions that lead to functional properties of mature articular cartilage.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Harjula, TerhiDepartment of Anatomy, Institute of Biomedicine, University of Kuopio, Kuopio, Finland (författare)
  • Iivarinen, JarkkoDepartment of Anatomy, Institute of Biomedicine, University of Kuopio, Kuopio, Finland (författare)
  • Marjanen, JuhoDepartment of Anatomy, Institute of Biomedicine, University of Kuopio, Kuopio, Finland (författare)
  • Seppänen, KariDepartment of Biosciences, Laboratory of Chemistry, University of Kuopio, Kuopio, Finland (författare)
  • Närhi, TommiDepartment of Anatomy, Institute of Biomedicine, University of Kuopio, Kuopio, Finland (författare)
  • Arokoski, JariDepartment of Physical and Rehabilitation Medicine, Kuopio University Hospitsl, Kuopio, Finland; Institute of Clinical Medicine, University of Kuopio, Kuopio, Finland (författare)
  • Lammi, Mikko,1961-Department of Biosciences, Applied Biotechnology, University of Kuopio, Finland; Biocenter Kuopio, University of Kuopio, Finland,Chondrogenic and Osteogenic Differentiation Group(Swepub:umu)mila0077 (författare)
  • Brama, PieterSection of Veterinary Clinical Studies, School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Dublin, Ireland (författare)
  • Jurvelin, JukkaDepartment of Physics, University of Kuopio, Kuopio, Finland (författare)
  • Helminen, HeikkiDepartment of Anatomy, Institute of Biomedicine, University of Kuopio, Kuopio, Finland (författare)
  • Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland; Department of Clinical Radiology, Kuopio University Hospital, Kuopio, FinlandDepartment of Anatomy, Institute of Biomedicine, University of Kuopio, Kuopio, Finland (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Osteoarthritis and Cartilage: Saunders Elsevier17:12, s. 1628-16381063-45841522-9653

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