Stress-relaxation of human patellar articular cartilage in unconfined compression: prediction of mechanical response by tissue composition and structure.

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Julkunen, PetroDepartment of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland; Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland (författare)

Stress-relaxation of human patellar articular cartilage in unconfined compression : prediction of mechanical response by tissue composition and structure.

Artikel/kapitelEngelska2008

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Elsevier,2008
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LIBRIS-ID:oai:DiVA.org:umu-106582
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-106582URI
https://doi.org/10.1016/j.jbiomech.2008.03.026DOI

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Språk:engelska
Sammanfattning på:engelska &language:-1_t

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Ämneskategori:art swepub-publicationtype

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Mechanical properties of articular cartilage are controlled by tissue composition and structure. Cartilage function is sensitively altered during tissue degeneration, in osteoarthritis (OA). However, mechanical properties of the tissue cannot be determined non-invasively. In the present study, we evaluate the feasibility to predict, without mechanical testing, the stress-relaxation response of human articular cartilage under unconfined compression. This is carried out by combining microscopic and biochemical analyses with composition-based mathematical modeling. Cartilage samples from five cadaver patellae were mechanically tested under unconfined compression. Depth-dependent collagen content and fibril orientation, as well as proteoglycan and water content were derived by combining Fourier transform infrared imaging, biochemical analyses and polarized light microscopy. Finite element models were constructed for each sample in unconfined compression geometry. First, composition-based fibril-reinforced poroviscoelastic swelling models, including composition and structure obtained from microscopical and biochemical analyses were fitted to experimental stress-relaxation responses of three samples. Subsequently, optimized values of model constants, as well as compositional and structural parameters were implemented in the models of two additional samples to validate the optimization. Theoretical stress-relaxation curves agreed with the experimental tests (R=0.95-0.99). Using the optimized values of mechanical parameters, as well as composition and structure of additional samples, we were able to predict their mechanical behavior in unconfined compression, without mechanical testing (R=0.98). Our results suggest that specific information on tissue composition and structure might enable assessment of cartilage mechanics without mechanical testing.

Ämnesord och genrebeteckningar

NATURVETENSKAP Biologi Biofysik hsv//swe
NATURAL SCIENCES Biological Sciences Biophysics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Ortopedi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Orthopaedics hsv//eng
Articular cartilage
finite element analysis
quantitative microscopy
collagen content
fixed charge density
proteoglycans
water fraction
unconfined compression
biomechanics
biomekanik
cell research
cellforskning

Biuppslag (personer, institutioner, konferenser, titlar ...)

Wilson, WouterDepartment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands (författare)
Jurvelin, JukkaDepartment of Physics, University of Kuopio, Kuopio, Finland; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland (författare)
Rieppo, JarnoDepartment of Biomedicine, Anatomy, University of Kuopio, Kuopio, FinlandDepartment of Biomedicine, Anatomy, University of Kuopio, Kuopio, Finland (författare)
Qu, Cheng-Juan,1967-Department of Biomedicine, Anatomy, University of Kuopio, Kuopio, Finland,Chondrogenic and Osteogenic Differentiation Group(Swepub:umu)chqu0007 (författare)
Lammi, Mikko,1961-Department of Biosciences, Applied Biotechnology, University of Kuopio, Kuopio, Finland,Chondrogenic and Osteogenic Differentiation Group(Swepub:umu)mila0077 (författare)
Korhonen, RamiDepartment of Physics, University of Kuopio, Kuopio, Finland; Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada (författare)
Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland; Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, FinlandDepartment of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands (creator_code:org_t)

Sammanhörande titlar

Ingår i:Journal of Biomechanics: Elsevier41:9, s. 1978-860021-92901873-2380

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Av författaren/redakt...: Julkunen, Petro; Wilson, Wouter; Jurvelin, Jukka; Rieppo, Jarno; Qu, Cheng-Juan, ...; Lammi, Mikko, 19 ...; visa fler...; Korhonen, Rami; visa färre...

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NATURVETENSKAP: NATURVETENSKAP; och Biologi; och Biofysik

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Av lärosätet: Umeå universitet

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