Sökning: onr:"swepub:oai:DiVA.org:umu-109376" > Widespread non-addi...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04381naa a2200769 4500 | |
001 | oai:DiVA.org:umu-109376 | |
003 | SwePub | |
008 | 150925s2015 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:131933968 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1093762 URI |
024 | 7 | a https://doi.org/10.1038/ng.33792 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1319339682 URI |
040 | a (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Lenz, Tobias L.4 aut |
245 | 1 0 | a Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases |
264 | c 2015-08-10 | |
264 | 1 | b Macmillan Publishers Ltd.c 2015 |
338 | a print2 rdacarrier | |
520 | a Human leukocyte antigen (HLA) genes confer substantial risk for autoimmune diseases on a log-additive scale. Here we speculated that differences in autoantigen-binding repertoires between a heterozygote's two expressed HLA variants might result in additional non-additive risk effects. We tested the non-additive disease contributions of classical HLA alleles in patients and matched controls for five common autoimmune diseases: rheumatoid arthritis (n(cases) = 5,337), type 1 diabetes (T1D; n(cases) = 5,567), psoriasis vulgaris (n(cases) = 3,089), idiopathic achalasia (n(cases) = 727) and celiac disease (ncases = 11,115). In four of the five diseases, we observed highly significant, non-additive dominance effects (rheumatoid arthritis, P = 2.5 x 10(-12); T1D, P = 2.4 x 10(-10); psoriasis, P = 5.9 x 10(-6); celiac disease, P = 1.2 x 10(-87)). In three of these diseases, the non-additive dominance effects were explained by interactions between specific classical HLA alleles (rheumatoid arthritis, P = 1.8 x 10(-3); T1D, P = 8.6 x 10(-27); celiac disease, P = 6.0 x 10(-100)). These interactions generally increased disease risk and explained moderate but significant fractions of phenotypic variance (rheumatoid arthritis, 1.4%; T1D, 4.0%; celiac disease, 4.1%) beyond a simple additive model. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
700 | 1 | a Deutsch, Aaron J.4 aut |
700 | 1 | a Han, Buhm4 aut |
700 | 1 | a Hu, Xinli4 aut |
700 | 1 | a Okada, Yukinori4 aut |
700 | 1 | a Eyre, Stephen4 aut |
700 | 1 | a Knapp, Michael4 aut |
700 | 1 | a Zhernakova, Alexandra4 aut |
700 | 1 | a Huizinga, Tom W. J.4 aut |
700 | 1 | a Abecasis, Goncalo4 aut |
700 | 1 | a Becker, Jessica4 aut |
700 | 1 | a Boeckxstaens, Guy E.4 aut |
700 | 1 | a Chen, Wei-Min4 aut |
700 | 1 | a Franke, Andre4 aut |
700 | 1 | a Gladman, Dafna D.4 aut |
700 | 1 | a Gockel, Ines4 aut |
700 | 1 | a Gutierrez-Achury, Javier4 aut |
700 | 1 | a Martin, Javier4 aut |
700 | 1 | a Nair, Rajan P.4 aut |
700 | 1 | a Noethen, Markus M.4 aut |
700 | 1 | a Onengut-Gumuscu, Suna4 aut |
700 | 1 | a Rahman, Proton4 aut |
700 | 1 | a Rantapää-Dahlqvist, Solbritt,d 1947-u Umeå universitet,Reumatologi4 aut0 (Swepub:umu)sora0001 |
700 | 1 | a Stuart, Philip E.4 aut |
700 | 1 | a Tsoi, Lam C.4 aut |
700 | 1 | a van Heel, David A.4 aut |
700 | 1 | a Worthington, Jane4 aut |
700 | 1 | a Wouters, Mira M.4 aut |
700 | 1 | a Klareskog, Larsu Karolinska Institutet4 aut |
700 | 1 | a Elder, James T.4 aut |
700 | 1 | a Gregersen, Peter K.4 aut |
700 | 1 | a Schumacher, Johannes4 aut |
700 | 1 | a Rich, Stephen S.4 aut |
700 | 1 | a Wijmenga, Cisca4 aut |
700 | 1 | a Sunyaev, Shamil R.4 aut |
700 | 1 | a de Bakker, Paul I. W.4 aut |
700 | 1 | a Raychaudhuri, Soumya4 aut |
710 | 2 | a Umeå universitetb Reumatologi4 org |
773 | 0 | t Nature Geneticsd : Macmillan Publishers Ltd.g 47:9, s. 1085-1090q 47:9<1085-1090x 1061-4036x 1546-1718 |
856 | 4 | u https://europepmc.org/articles/pmc4552599?pdf=render |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-109376 |
856 | 4 8 | u https://doi.org/10.1038/ng.3379 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:131933968 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy