Oncological outcome after incidental perforation in radical rectal cancer surgery

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Jörgren, FredrikLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups (författare)

Oncological outcome after incidental perforation in radical rectal cancer surgery

Artikel/kapitelEngelska2010

Förlag, utgivningsår, omfång ...

2010-03-27
Springer Science and Business Media LLC,2010
printrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:umu-109623
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-109623URI
https://doi.org/10.1007/s00384-010-0930-9DOI
https://lup.lub.lu.se/record/1581462URI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:ref swepub-contenttype
Ämneskategori:art swepub-publicationtype

Anmärkningar

Identification of risk factors of poor oncological outcome in rectal cancer surgery is of utmost importance. This study examines the impact of incidental perforation on the oncological outcome. Using the Swedish Rectal Cancer Registry, patients were selected who received major abdominal surgery for rectal cancer between 1995 and 1997 with registered incidental perforation. A control group was also selected for analysis of the oncological outcome after 5-year follow-up. Multivariate analysis was performed. Registry data were validated, and additional data were supplemented from medical records. After validation and exclusion of non-radically operated patients, 118 patients with incidental perforation and 155 controls in TNM stages I-III were included in the analysis. The rate of local recurrence (LR) [20% (23/118) vs. 8% (12/155) (p = 0.007)] was significantly higher among patients with perforation, whereas the rates of distant metastasis [27% (32/118) vs. 21% (33/155) (p = 0.33)] and overall recurrence (OAR) [35% (41/118) vs. 25% (38/155) (p = 0.087)] were not significantly different between the groups. Overall as well as cancer-specific 5-year survival rates were significantly reduced for the patients with perforation [44 vs. 64% (p = 0.002) and 66 vs. 80% (p = 0.026), respectively]. In the multivariate analysis, perforation was a significant risk factor of increased rates of LR and OAR as well as reduced 5-year overall and cancer-specific survival. Incidental perforation in rectal cancer surgery is an important risk factor of poor oncological outcome and should be considered in the discussion concerning postoperative adjuvant treatment as well as the follow-up regime.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Gastroenterologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Gastroenterology and Hepatology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
Rectal neoplasms
Intestinal perforation
Neoplasm recurrence local
Neoplasm metastasis
Survival rate
Risk factors

Biuppslag (personer, institutioner, konferenser, titlar ...)

Johansson, RobertUmeå universitet,Onkologi(Swepub:umu)rojo0001 (författare)
Damber, LenaUmeå universitet,Onkologi(Swepub:umu)leda0008 (författare)
Lindmark, GudrunLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups(Swepub:lu)med-gli (författare)
KirurgiForskargrupper vid Lunds universitet (creator_code:org_t)

Sammanhörande titlar

Ingår i:International Journal of Colorectal Disease: Springer Science and Business Media LLC25:6, s. 731-7400179-19581432-1262

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International Journal of Colorectal Disease (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Jörgren, Fredrik; Johansson, Rober ...; Damber, Lena; Lindmark, Gudrun

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Gastroenterologi

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kirurgi

Artiklar i publikationen: International Jo ...

Av lärosätet: Umeå universitet; Lunds universitet

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