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Secreted Factors fr...
Secreted Factors from Colorectal and Prostate Cancer Cells Skew the Immune Response in Opposite Directions
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- Lundholm, Marie (författare)
- Umeå universitet,Patologi
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- Hägglöf, Christina (författare)
- Umeå universitet,Patologi
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- Wikberg, Maria L. (författare)
- Umeå universitet,Patologi
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- Stattin, Pär (författare)
- Uppsala universitet,Umeå universitet,Urologi och andrologi,Urologkirurgi,Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, Umeå, Sweden
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- Egevad, Lars (författare)
- Karolinska Institutet
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- Bergh, Anders (författare)
- Umeå universitet,Patologi,anders.bergh@umu.se
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- Wikström, Pernilla (författare)
- Umeå universitet,Patologi
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- Palmqvist, Richard (författare)
- Umeå universitet,Patologi
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- Edin, Sofia (författare)
- Umeå universitet,Patologi
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(creator_code:org_t)
- 2015-10-27
- 2015
- Engelska.
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Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 5
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://umu.diva-por...
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Macrophage infiltration has been associated with an improved prognosis in patients with colorectal cancer (CRC), but a poor prognosis in prostate cancer (PC) patients. In this study, the distribution and prognostic value of proinflammatory M1 macrophages (NOS2(+)) and immunosuppressive M2 macrophages (CD163(+)) was evaluated in a cohort of 234 PC patients. We found that macrophages infiltrating PC were mainly of an M2 type and correlated with a more aggressive tumor and poor patient prognosis. Furthermore, the M1/M2 ratio was significantly decreased in PC compared to CRC. Using in vitro cell culture experiments, we could show that factors secreted from CRC and PC cells induced macrophages of a proinflammatory or immunosuppressive phenotype, respectively. These macrophages differentially affected autologous T lymphocyte proliferation and activation. Consistent with this, CRC specimens were found to have higher degrees of infiltrating T-helper 1 cells and active cytotoxic T lymphocytes, while PC specimens displayed functionally inactive T cells. In conclusion, our results imply that tumour-secreted factors from cancers of different origin can drive macrophage differentiation in opposite directions and thereby regulate the organization of the anti-tumour immune response. Our findings suggest that reprogramming of macrophages could be an important tool in the development of new immunotherapeutic strategies.
Ämnesord
- LANTBRUKSVETENSKAPER -- Veterinärmedicin -- Medicinsk biovetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science -- Medical Bioscience (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- art (ämneskategori)
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