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Sökning: onr:"swepub:oai:DiVA.org:umu-114" > Incidence trends an...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004224nam a2200517 4500
001oai:DiVA.org:umu-114
003SwePub
008031001s2003 | |||||||||||000 ||eng|
020 a 9173055190q print
024a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1142 URI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a vet2 swepub-contenttype
072 7a dok2 swepub-publicationtype
100a Pundziute-Lyckå, Auste,d 1968-u Umeå universitet,Pediatrik4 aut
2451 0a Incidence trends and environmental determinants of type 1 diabetes in Lithuania and Sweden
264 1a Umeå :b Umeå university,c 2003
300 a 70 s.
338 a electronic2 rdacarrier
490a Umeå University medical dissertations,x 0346-6612 ;v 853
520 a Variation of diabetes incidence over time in countries with different incidence levels and socio-economic conditions, and in an age span beyond the childhood years, may give clues for diabetes causes.Materials: Data from prospective type 1 diabetes registers in Sweden and Lithuania in children (0-14 years) and young adults (15-34 and 15-39 years, respectively). Number of infections recorded in health care booklets (117 cases; 270 controls); interview about the dietary intake one-year before the diagnosis and routinely recorded growth data (99 cases; 180 controls).Results: The incidence of type 1 diabetes in Sweden and Lithuania differed most in the younger age groups, 28.9 and 7.5/100,000/year in 0-14-year group, respectively. During 1983-2000 incidence increased in 0-14-year old children in both countries, but the pattern of change differed. During 1983-1998 the incidence increased in Swedish children, but tended to decrease in young adults, with no increase in the age group below 35 years, indicating that the increase of childhood diabetes may be due to a shift towards a younger age at diagnosis. Within a low-incidence country Lithuania there was an urban-rural gradient of incidence, especially in the younger age groups, that seemed to follow poverty distribution: incidence in the 0-39-year group was 7.1, 9.0 and 8.8/100,000/year in rural areas, towns and cities, respectively, p<0.001.Exposure to one or more non-specific infection during the first half-year of life reduced diabetes risk: odds ratios (95%-CI) in 0-14 and 5-14-year groups were (0.60; 0.37-0.98) and (0.47; 0.26-0.87), respectively. Higher energy intake and weight-for-age were independent diabetes risk factors: odds ratios for medium and high levels of energy were 1.33 (0.52-3.42) and 5.23 (1.67-16.38), and for weight-for-age 3.20 (1.30-7.88) and 3.09 (1.16-8.22), respectively. High intake of carbohydrates, disaccharides and sucrose in particular, increased diabetes risk independently of the high intake of energy.Conclusion: Environmental factors associated with socio-economic conditions in childhood may be important for the occurrence of type 1 diabetes. Lack of exposure to microbial antigens early in life, higher intake of energy and more rapid growth may contribute to the increase of childhood-onset diabetes observed in many countries.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng
653 a Pediatrics
653 a type 1 diabetes mellitus
653 a epidemiology
653 a childhood
653 a incidence
653 a secular trend
653 a case-control study
653 a risk factors
653 a infections
653 a energy
653 a weight
653 a Pediatrik
653 a Paediatric medicine
653 a Pediatrisk medicin
653 a pediatrik
653 a Pediatrics
700a Dahlquist, Gisela4 ths
700a Urbonaite, Brone4 ths
700a Åkerblom, Hans Kristian,c Professor emeritusu Biomedicum, Helsingfors Universitet, Helsingfors4 opn
710a Umeå universitetb Pediatrik4 org
856u https://umu.diva-portal.org/smash/get/diva2:140357/FULLTEXT01.pdfx primaryx Raw objecty fulltext
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-114

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