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Facile Synthesis of...
Facile Synthesis of 4-Oxo-4H-quinolizine-2-carboxamide Derivatives
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Bui, Hue T B (författare)
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- Vo, Duy D (författare)
- Umeå universitet,Kemiska institutionen,Umeå Centre for Microbial Research (UCMR)
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Chau, Yen N T (författare)
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Tu, Cuc T K (författare)
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Mai, Hieu V (författare)
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Truong, Kiet V (författare)
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(creator_code:org_t)
- 2015-11-03
- 2015
- Engelska.
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Ingår i: Synthetic Communications. - : Taylor & Francis. - 0039-7911 .- 1532-2432. ; 45:24, s. 2861-2868
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- A facile synthetic method for the construction of 2-substituted-4-oxo-4H-quinolizine-based core structure has been successfully developed. The synthesis made use of a one-pot Stobbe condensation followed by cyclization starting from the commercially available 2-pyridinecarbaldehyde. The structure of the formed 4-oxo-4H-quinolizine-2-carboxylate was fully confirmed by mass spectra, H-1 NMR and C-13 NMR, correlation spectrography, heteronuclear multiple bond correlation, and heteronuclear single quantum coherence (HSQC) spectra. The ethyl carboxylate moiety was then further functionalized via direct aminolysis by a range of amines to afford the corresponding 4-oxo-4H-quinolizine-2-carboxamides 4a-i in moderate to good yields.
Ämnesord
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Nyckelord
- Carboxamide
- 4-oxo-4H-quinolizine
- Stobbe condensation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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