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Carbamate linker st...
Carbamate linker strategy in solid-phase synthesis of amino-functionalized glycoconjugates for attachment to solid surfaces and investigation of protein-carbohydrate interactions
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- Spjut, Sara, 1978- (författare)
- Umeå universitet,Kemiska institutionen
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- Pudelko, Maciej, 1978- (författare)
- Institut für Organische Chemie, Universität Mainz, Duesbergweg 10-14, 55128 Mainz, Germany
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- Hartmann, Mirja (författare)
- Otto Diels Institute of Organic Chemistry, Christiana Albertina University of Kiel,Otto-Hahn-Platz 4, 24098 Kiel, Germany
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- Elofsson, Mikael (författare)
- Umeå universitet,Kemiska institutionen
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(creator_code:org_t)
- Weinheim : WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, 2009
- 2009
- Engelska.
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Ingår i: European Journal of Organic Chemistry. - Weinheim : WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. - 1434-193X .- 1099-0690. ; :3, s. 349-57
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Amino-functionalized serine-based galactose and glucose neoglycolipids were prepared by solid-phase synthesis using a carbamate strategy for anchoring amino functionalities to a (2-fluoro-4-hydroxymethylphenoxy)acetic acid linker resin. Key synthetic steps were monitored with gel-phase 19F NMR spectroscopy. Cleavage from the solid support was performed with trifluoroacetic acid. The terminal amine of the neoglycolipids was conjugated with didecyl squarate and then immobilized in amino-functionalized microtiter plates and the glycoconjugates were successfully probed with a galactose-binding lectin.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Andra medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Other Basic Medicine (hsv//eng)
Nyckelord
- Solid-phase synthesis
- Glycoconjugates
- Carbohydrates
- Proteins
- Carbohydrate protein interactions
- Carbamate linker
- Gel-phase 19F NMR spectroscopy
- Microtiter plates
- Chemistry
- Kemi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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