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Modular gene expres...
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Grönlund, AndreasUmeå universitet,Institutionen för fysiologisk botanik,Umeå Plant Science Center Department of Forest Genetics and Plant Physiology, University of Agricultural Sciences, Umeå, Sweden
(författare)
Modular gene expression in Poplar : a multilayer network approach
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
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2008-12-16
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Wiley,2009
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-11508
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-11508URI
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https://doi.org/10.1111/j.1469-8137.2008.02668.xDOI
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https://res.slu.se/id/publ/19850URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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* By applying a multilayer network approach to an extensive set of Poplar microarray data, a genome-wide coexpression network has been detected and explored. * Multilayer networks were generated from minimum spanning trees (MSTs) using Kruskal's algorithm from random jack-knife resamplings of half of the full data set. The final network is obtained from the union of all the generated MSTs. * The gene expression correlations display a highly clustered topology, which is more pronounced when introducing links appearing in relatively few of the generated MSTs. The network also reveals a modular architecture, reflecting functional groups with relatively frequent gene-to-gene communication. Furthermore, the observed modular structure overlaps with different gene activities in different tissues, and closely related tissues show similar over- and/or under-expression patterns at the modular scale. * It is shown that including links that appear in a few of the generated MSTs increases the information quality of the network. In other words, a link may be 'weak' because it reflects rare signaling events rather than merely a signal weakened by noise. The method allows, from comparisons of random 'null networks', tuning to maximize the information obtainable.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Bhalerao, Rishikesh P.Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Umeå universitet,Umeå Plant Science Centre (UPSC),Institutionen för skoglig genetik och växtfysiologi,Department of Forest Genetics and Plant Physiology(Swepub:slu)48176
(författare)
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Karlsson, JanUmeå universitet,Institutionen för fysiologisk botanik,Umeå Plant Science Centre (UPSC)(Swepub:umu)jaka0002
(författare)
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Umeå universitetInstitutionen för fysiologisk botanik
(creator_code:org_t)
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Sveriges lantbruksuniversitet
Sammanhörande titlar
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Ingår i:New Phytologist: Wiley181:2, s. 315-3220028-646X1469-8137
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