Sökning: onr:"swepub:oai:DiVA.org:umu-116966" > The 12p13.33/RAD52 ...
Fältnamn | Indikatorer | Metadata |
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000 | 04610naa a2200925 4500 | |
001 | oai:DiVA.org:umu-116966 | |
003 | SwePub | |
008 | 160216s2015 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1169662 URI |
024 | 7 | a https://doi.org/10.1371/journal.pone.01176392 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Delahaye-Sourdeix, Manon4 aut |
245 | 1 0 | a The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract |
264 | c 2015-03-20 | |
264 | 1 | b Public library science,c 2015 |
338 | a print2 rdacarrier | |
520 | a Genetic variants located within the 12p13.33/RAD52 locus have been associated with lung squamous cell carcinoma (LUSC). Here, within 5,947 UADT cancers and 7,789 controls from 9 different studies, we found rs10849605, a common intronic variant in RAD52, to be also associated with upper aerodigestive tract (UADT) squamous cell carcinoma cases (OR = 1.09, 95% CI: 1.04-1.15, p = 6x10(-4)). We additionally identified rs10849605 as a RAD52 cis-eQTL inUADT(p = 1x10(-3)) and LUSC (p = 9x10(-4)) tumours, with the UADT/LUSC risk allele correlated with increased RAD52 expression levels. The 12p13.33 locus, encompassing rs10849605/RAD52, was identified as a significant somatic focal copy number amplification in UADT(n = 374, q-value = 0.075) and LUSC (n = 464, q-value = 0.007) tumors and correlated with higher RAD52 tumor expression levels (p = 6x10(-48) and p = 3x10(-29) in UADT and LUSC, respectively). In combination, these results implicate increased RAD52 expression in both genetic susceptibility and tumorigenesis of UADT and LUSC tumors. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a Oliver, Javier4 aut |
700 | 1 | a Timofeeva, Maria N4 aut |
700 | 1 | a Gaborieau, Valérie4 aut |
700 | 1 | a Johansson, Mattiasu Genetic Epidemiology group (GEP), International Agency for Research on Cancer (IARC), Lyon, France4 aut0 (Swepub:umu)masmas97 |
700 | 1 | a Chabrier, Amélie4 aut |
700 | 1 | a Wozniak, Magdalena B4 aut |
700 | 1 | a Brenner, Darren R4 aut |
700 | 1 | a Vallée, Maxime P4 aut |
700 | 1 | a Anantharaman, Devasena4 aut |
700 | 1 | a Lagiou, Pagona4 aut |
700 | 1 | a Holcátová, Ivana4 aut |
700 | 1 | a Richiardi, Lorenzo4 aut |
700 | 1 | a Kjaerheim, Kristina4 aut |
700 | 1 | a Agudo, Antonio4 aut |
700 | 1 | a Castellsagué, Xavier4 aut |
700 | 1 | a Macfarlane, Tatiana V4 aut |
700 | 1 | a Barzan, Luigi4 aut |
700 | 1 | a Canova, Cristina4 aut |
700 | 1 | a Thakker, Nalin S4 aut |
700 | 1 | a Conway, David I4 aut |
700 | 1 | a Znaor, Ariana4 aut |
700 | 1 | a Healy, Claire M4 aut |
700 | 1 | a Ahrens, Wolfgang4 aut |
700 | 1 | a Zaridze, David4 aut |
700 | 1 | a Szeszenia-Dabrowska, Neonilia4 aut |
700 | 1 | a Lissowska, Jolanta4 aut |
700 | 1 | a Fabianova, Eleonora4 aut |
700 | 1 | a Mates, Ioan Nicolae4 aut |
700 | 1 | a Bencko, Vladimir4 aut |
700 | 1 | a Foretova, Lenka4 aut |
700 | 1 | a Janout, Vladimir4 aut |
700 | 1 | a Curado, Maria Paula4 aut |
700 | 1 | a Koifman, Sergio4 aut |
700 | 1 | a Menezes, Ana4 aut |
700 | 1 | a Wünsch-Filho, Victor4 aut |
700 | 1 | a Eluf-Neto, José4 aut |
700 | 1 | a Boffetta, Paolo4 aut |
700 | 1 | a Garrote, Leticia Fernández4 aut |
700 | 1 | a Serraino, Diego4 aut |
700 | 1 | a Lener, Marcin4 aut |
700 | 1 | a Jaworowska, Ewa4 aut |
700 | 1 | a Lubiński, Jan4 aut |
700 | 1 | a Boccia, Stefania4 aut |
700 | 1 | a Rajkumar, Thangarajan4 aut |
700 | 1 | a Samant, Tanuja A4 aut |
700 | 1 | a Mahimkar, Manoj B4 aut |
700 | 1 | a Matsuo, Keitaro4 aut |
700 | 1 | a Franceschi, Silvia4 aut |
700 | 1 | a Byrnes, Graham4 aut |
700 | 1 | a Brennan, Paul4 aut |
700 | 1 | a McKay, James D4 aut |
710 | 2 | a Genetic Epidemiology group (GEP), International Agency for Research on Cancer (IARC), Lyon, France4 org |
773 | 0 | t PLOS ONEd : Public library scienceg 10:3q 10:3x 1932-6203 |
856 | 4 | u https://doi.org/10.1371/journal.pone.0117639y Fulltext |
856 | 4 | u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0117639&type=printable |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-116966 |
856 | 4 8 | u https://doi.org/10.1371/journal.pone.0117639 |
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