SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:umu-119010"
 

Sökning: onr:"swepub:oai:DiVA.org:umu-119010" > Antidepressant use ...

  • Boström, GustafUmeå universitet,Geriatrik (författare)

Antidepressant use and mortality in very old people

  • Artikel/kapitelEngelska2016

Förlag, utgivningsår, omfång ...

  • Cambridge University Press,2016
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-119010
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-119010URI
  • https://doi.org/10.1017/S104161021600048XDOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BACKGROUND: Antidepressant treatment may increase the risk of death. The association between antidepressants and mortality has been evaluated in community-dwelling older people, but not in representative samples of very old people, among whom dementia, multimorbidity, and disability are common.METHODS: Umeå 85+/GERDA study participants (n = 992) aged 85, 90, and ≥95 years were followed for up to five years. Cox proportional hazard regression models were used to analyze mortality risk associated with baseline antidepressant treatment, adjusted for potential confounders.RESULTS: Mean age was 89 years; 27% of participants had dementia, 20% had stroke histories, 29% had heart failure, and 16% used antidepressants. In age- and sex-adjusted analyses, antidepressant use was associated with a 76% increased mortality risk (hazard ratio [HR] = 1.76; 95% confidence interval [CI], 1.41-2.19). Adding adjustment for Geriatric Depression Scale score, HR was 1.62 (95% CI, 1.29-2.03). The association was not significant when adjusting for additional confounding factors (HR = 1.08; 95% CI, 0.85-1.38). Interaction analyses in the fully adjusted model revealed a significant interaction between sex and antidepressant use (HR: 1.76; 95% CI, 1.05-2.94). Among male and female antidepressant users, the HRs for death were 0.76 (95% CI, 0.47-1.24) and 1.28 (95% CI, 0.97-1.70), respectively.CONCLUSION: Among very old people, baseline antidepressant treatment does not seem to be independently associated with increased mortality risk. However, the risk may be different in men and women. This difference and the potential risk of initial treatment require further investigation in future cohort studies of very old people.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Hörnsten, CarlUmeå universitet,Geriatrik(Swepub:umu)calhon04 (författare)
  • Brännström, JonUmeå universitet,Geriatrik(Swepub:umu)jobr0009 (författare)
  • Conradsson, MiaUmeå universitet,Geriatrik(Swepub:umu)miacon02 (författare)
  • Nordström, PeterUmeå universitet,Geriatrik(Swepub:umu)peno0014 (författare)
  • Allard, PerUmeå universitet,Psykiatri(Swepub:umu)peal0001 (författare)
  • Gustafson, YngveUmeå universitet,Geriatrik(Swepub:umu)yngu0001 (författare)
  • Littbrand, HåkanUmeå universitet,Geriatrik(Swepub:umu)hanlid85 (författare)
  • Umeå universitetGeriatrik (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:International psychogeriatrics: Cambridge University Press28:7, s. 1201-12101041-61021741-203X

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Sök utanför SwePub

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy