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Epidemiology of Acu...
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Cohen, Cheryl
(författare)
Epidemiology of Acute Lower Respiratory Tract Infection in HIV-Exposed Uninfected Infants
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
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2016-04-01
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American Academy of Pediatrics,2016
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-119651
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-119651URI
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https://doi.org/10.1542/peds.2015-3272DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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BACKGROUND: Increased morbidity and mortality from lower respiratory tract infection (LRTI) has been suggested in HIV-exposed uninfected (HEU) children; however, the contribution of respiratory viruses is unclear. We studied the epidemiology of LRTI hospitalization in HIV-unexposed uninfected (HUU) and HEU infants aged <6 months in South Africa. METHODS: We prospectively enrolled hospitalized infants with LRTI from 4 provinces from 2010 to 2013. Using polymerase chain reaction, nasopharyngeal aspirates were tested for 10 viruses and blood for pneumococcal DNA. Incidence for 2010-2011 was estimated at 1 site with population denominators. RESULTS: We enrolled 3537 children aged <6 months. HIV infection and exposure status were determined for 2507 (71%), of whom 211 (8%) were HIV infected, 850 (34%) were HEU, and 1446 (58%) were HUU. The annual incidence of LRTI was elevated in HEU (incidence rate ratio [IRR] 1.4; 95% confidence interval [CI] 1.3-1.5) and HIV infected (IRR 3.8; 95% CI 3.3-4.5), compared with HUU infants. Relative incidence estimates were greater in HEU than HUU, for respiratory syncytial virus (RSV; IRR 1.4; 95% CI 1.3-1.6) and human metapneumovirus-associated (IRR 1.4; 95% CI 1.1-2.0) LRTI, with a similar trend observed for influenza (IRR 1.2; 95% CI 0.8-1.8). HEU infants overall, and those with RSV-associated LRTI had greater odds (odds ratio 2.1, 95% CI 1.1-3.8, and 12.2, 95% CI 1.7-infinity, respectively) of death than HUU. CONCLUSIONS: HEU infants were more likely to be hospitalized and to die in-hospital than HUU, including specifically due to RSV. This group should be considered a high-risk group for LRTI.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Moyes, Jocelyn
(författare)
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Tempia, Stefano
(författare)
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Groome, Michelle
(författare)
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Walaza, Sibongile
(författare)
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Pretorius, Marthi
(författare)
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Naby, Fathima
(författare)
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Mekgoe, Omphile
(författare)
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Kahn, KathleenUmeå universitet,Epidemiologi och global hälsa,MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences; INDEPTH Network, Accra, Ghana(Swepub:umu)kaka0045
(författare)
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von Gottberg, Anne
(författare)
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Wolter, Nicole
(författare)
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Cohen, Adam L.
(författare)
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von Mollendorf, Claire
(författare)
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Venter, Marietjie
(författare)
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Madhi, Shabir A.
(författare)
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Umeå universitetEpidemiologi och global hälsa
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Pediatrics: American Academy of Pediatrics137:40031-40051098-4275
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Cohen, Cheryl
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Moyes, Jocelyn
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Tempia, Stefano
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Groome, Michelle
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Walaza, Sibongil ...
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Pretorius, Marth ...
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visa fler...
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Naby, Fathima
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Mekgoe, Omphile
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Kahn, Kathleen
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von Gottberg, An ...
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Wolter, Nicole
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Cohen, Adam L.
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von Mollendorf, ...
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Venter, Marietji ...
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Madhi, Shabir A.
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