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FältnamnIndikatorerMetadata
00009356naa a2200901 4500
001oai:DiVA.org:umu-120629
003SwePub
008160518s2016 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:133289525
009oai:DiVA.org:uu-422330
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1206292 URI
0247 a https://doi.org/10.1186/s12916-016-0607-52 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1332895252 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4223302 URI
040 a (SwePub)umud (SwePub)kid (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Ordóñez-Mena, José Manuelu Heidelberg Univ, Network Aging Res, Heidelberg, Germany.;German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Neuenheimer Feld 581, D-69120 Heidelberg, Germany.4 aut
2451 0a Quantification of the smoking-associated cancer risk with rate advancement periods :b meta-analysis of individual participant data from cohorts of the CHANCES consortium
264 c 2016-04-05
264 1b Springer Science and Business Media LLC,c 2016
338 a electronic2 rdacarrier
520 a Background: Smoking is the most important individual risk factor for many cancer sites but its association with breast and prostate cancer is not entirely clear. Rate advancement periods (RAPs) may enhance communication of smoking related risk to the general population. Thus, we estimated RAPs for the association of smoking exposure (smoking status, time since smoking cessation, smoking intensity, and duration) with total and site-specific (lung, breast, colorectal, prostate, gastric, head and neck, and pancreatic) cancer incidence and mortality.Methods: This is a meta-analysis of 19 population-based prospective cohort studies with individual participant data for 897,021 European and American adults. For each cohort we calculated hazard ratios (HRs) for the association of smoking exposure with cancer outcomes using Cox regression adjusted for a common set of the most important potential confounding variables. RAPs (in years) were calculated as the ratio of the logarithms of the HRs for a given smoking exposure variable and age. Meta-analyses were employed to summarize cohort-specific HRs and RAPs.Results: Overall, 140,205 subjects had a first incident cancer, and 53,164 died from cancer, during an average follow-up of 12 years. Current smoking advanced the overall risk of developing and dying from cancer by eight and ten years, respectively, compared with never smokers. The greatest advancements in cancer risk and mortality were seen for lung cancer and the least for breast cancer. Smoking cessation was statistically significantly associated with delays in the risk of cancer development and mortality compared with continued smoking.Conclusions: This investigation shows that smoking, even among older adults, considerably advances, and cessation delays, the risk of developing and dying from cancer. These findings may be helpful in more effectively communicating the harmful effects of smoking and the beneficial effect of smoking cessation.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Smoking
653 a Cancer
653 a Incidence
653 a Mortality
653 a Cohort
653 a Meta-analysis
7001 a Schöttker, Benu Heidelberg Univ, Network Aging Res, Heidelberg, Germany.;German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Neuenheimer Feld 581, D-69120 Heidelberg, Germany.4 aut
7001 a Mons, Uteu German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Neuenheimer Feld 581, D-69120 Heidelberg, Germany.4 aut
7001 a Jenab, Mazdau Int Agcy Res Canc, 150 Cours Albert Thomas, F-69372 Lyon, France.4 aut
7001 a Freisling, Heinzu Int Agcy Res Canc, 150 Cours Albert Thomas, F-69372 Lyon, France.4 aut
7001 a Bueno-de-Mesquita, Basu Natl Inst Publ Hlth & Environm RIVM, Dept Chron Dis, Bilthoven, Netherlands.;Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands.;Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Div Epidemiol & Biostat, London, England.;Univ Malaya, Dept Social Prevent Med, Fac Med, Kuala Lumpur, Malaysia.4 aut
7001 a O'Doherty, Mark G.u Queens Univ Belfast, UKCRC Ctr Excellence Publ Hlth, Belfast, Antrim, North Ireland.4 aut
7001 a Scott, Angelau Queens Univ Belfast, UKCRC Ctr Excellence Publ Hlth, Belfast, Antrim, North Ireland.4 aut
7001 a Kee, Franku Queens Univ Belfast, UKCRC Ctr Excellence Publ Hlth, Belfast, Antrim, North Ireland.4 aut
7001 a Stricker, Bruno H.u Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.4 aut
7001 a Hofman, Albertu Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.4 aut
7001 a de Keyser, Catherine E.u Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.4 aut
7001 a Ruiter, Rikjeu Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.4 aut
7001 a Söderberg, Stefanu Umeå universitet,Kardiologi,Heart Center,Umea Univ, Dept Publ Hlth & Clin Med, Cardiol & Heart Ctr, Umea, Sweden.4 aut0 (Swepub:umu)stso0001
7001 a Jousilahti, Pekkau Natl Inst Hlth & Welf THL, Helsinki, Finland.4 aut
7001 a Kuulasmaa, Kariu Natl Inst Hlth & Welf THL, Helsinki, Finland.4 aut
7001 a Freedman, Neal D.u NCI, Nutr Epidemiol Branch, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut
7001 a Wilsgaard, Tomu UiT Arctic Univ Norway, Dept Community Med, Tromso, Norway.4 aut
7001 a de Groot, Lisette C. P. G. M.u Wageningen Univ, Div Human Nutr, NL-6700 AP Wageningen, Netherlands.4 aut
7001 a Kampman, Ellenu Wageningen Univ, Div Human Nutr, NL-6700 AP Wageningen, Netherlands.4 aut
7001 a Håkansson, Niclasu Karolinska Institutet,Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden.4 aut
7001 a Orsini, Nicolau Karolinska Institutet,Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden.4 aut
7001 a Wolk, Alicjau Karolinska Institutet,Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden.4 aut
7001 a Nilsson, Lena Mariau Umeå universitet,Näringsforskning,Arktiskt centrum vid Umeå universitet (Arcum),Umea Univ, Dept Publ Hlth & Clin Med, Nutr Res, Arctic Res Ctr, Umea, Sweden.;Umea Univ, Arcum, Arctic Res Ctr, Umea, Sweden.4 aut0 (Swepub:umu)leni0002
7001 a Tjønneland, Anneu Danish Canc Soc, Res Ctr, Diet Genes & Environm, Copenhagen, Denmark.4 aut
7001 a Pająk, Andrzeju Jagiellonian Univ, Coll Med, Fac Hlth Sci, Krakow, Poland.4 aut
7001 a Malyutina, Sofiau Inst Internal & Prevent Med, Novosibirsk, Russia.4 aut
7001 a Kubínová, Růženau Natl Inst Publ Hlth, Prague, Czech Republic.4 aut
7001 a Tamosiunas, Abdonasu Lithuanian Univ Hlth Sci, Inst Cardiol, Kaunas, Lithuania.4 aut
7001 a Bobak, Martinu UCL, Dept Epidemiol & Publ Hlth, London, England.4 aut
7001 a Katsoulis, Michailu Hellen Hlth Fdn, Athens, Greece.4 aut
7001 a Orfanos, Philipposu Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece.4 aut
7001 a Boffetta, Paolou Hellen Hlth Fdn, Athens, Greece.;Icahn Sch Med Mt Sinai, Inst Translat Epidemiol, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA.4 aut
7001 a Trichopoulou, Antoniau Hellen Hlth Fdn, Athens, Greece.;Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece.4 aut
7001 a Brenner, Hermannu Heidelberg Univ, Network Aging Res, Heidelberg, Germany.;German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Neuenheimer Feld 581, D-69120 Heidelberg, Germany.;German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany.;German Canc Res Ctr, Div Prevent Oncol, Heidelberg, Germany.4 aut
7102 a Heidelberg Univ, Network Aging Res, Heidelberg, Germany.;German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Neuenheimer Feld 581, D-69120 Heidelberg, Germany.b German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Neuenheimer Feld 581, D-69120 Heidelberg, Germany.4 org
7730 t BMC Medicined : Springer Science and Business Media LLCg 14q 14x 1741-7015
8564 u https://doi.org/10.1186/s12916-016-0607-5y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:953226/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://bmcmedicine.biomedcentral.com/track/pdf/10.1186/s12916-016-0607-5
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-120629
8564 8u https://doi.org/10.1186/s12916-016-0607-5
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:133289525
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-422330

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