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c-fos antisense oli...
Abstract
Ämnesord
Stäng
- Extracellular electrophysiological recordings were used to study the firing rate of striatal neurons before and up to 4 h after intrastriatal c-fos antisense oligonucleotide injections in urethane-anesthetized rats. A four-fold increase from baseline neuronal activity was observed between 1 and 3 h upon antisense treatment, but not after control oligonucleotide injections. We conclude that, under urethane anesthesia, which here does not affect c-fos expression in the striatum by itself, neuronal activity appears to be tonically suppressed by basal striatal c-fos expression.
Nyckelord
- Action Potentials/drug effects/*genetics
- Anesthesia
- Animals
- Corpus Striatum/drug effects/*physiology
- Genes; fos/drug effects/*genetics
- Male
- Neurons/drug effects/*physiology
- Oligonucleotides; Antisense/*pharmacology
- Rats
- Rats; Sprague-Dawley
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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