Sökning: onr:"swepub:oai:DiVA.org:umu-124226" > A method to deciphe...
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000 | 03641naa a2200577 4500 | |
001 | oai:DiVA.org:umu-124226 | |
003 | SwePub | |
008 | 160728s2016 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:133834123 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1242262 URI |
024 | 7 | a https://doi.org/10.1038/ng.35722 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1338341232 URI |
040 | a (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Han, Buhm4 aut |
245 | 1 0 | a A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases |
264 | c 2016-05-16 | |
264 | 1 | b Springer Science and Business Media LLC,c 2016 |
338 | a print2 rdacarrier | |
520 | a There is growing evidence of shared risk alleles for complex traits (pleiotropy), including autoimmune and neuropsychiatric diseases. This might be due to sharing among all individuals (whole-group pleiotropy) or a subset of individuals in a genetically heterogeneous cohort (subgroup heterogeneity). Here we describe the use of a well-powered statistic, BUHMBOX, to distinguish between those two situations using genotype data. We observed a shared genetic basis for 11 autoimmune diseases and type 1 diabetes (T1D; P < 1 x 10(-4)) and for 11 autoimmune diseases and rheumatoid arthritis (RA; P < 1 x 10(-3)). This sharing was not explained by subgroup heterogeneity (corrected P-BUHMBOX > 0.2; 6,670 T1D cases and 7,279 RA cases). Genetic sharing between seronegative and seropostive RA (P < 1 x 10(-9)) had significant evidence of subgroup heterogeneity, suggesting a subgroup of seropositive-like cases within seronegative cases (P-BUHMBOX = 0.008; 2,406 seronegative RA cases). We also observed a shared genetic basis for major depressive disorder (MDD) and schizophrenia (P < 1 x 10(-4)) that was not explained by subgroup heterogeneity (P-BUHMBOX = 0.28; 9,238 MDD cases). | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
700 | 1 | a Pouget, Jennie G.4 aut |
700 | 1 | a Slowikowski, Kamil4 aut |
700 | 1 | a Stahl, Eli4 aut |
700 | 1 | a Lee, Cue Hyunkyu4 aut |
700 | 1 | a Diogo, Dorothee4 aut |
700 | 1 | a Hu, Xinli4 aut |
700 | 1 | a Park, Yu Rang4 aut |
700 | 1 | a Kim, Eunji4 aut |
700 | 1 | a Gregersen, Peter K.4 aut |
700 | 1 | a Dahlqvist, Solbritt Rantapääu Umeå universitet,Reumatologi4 aut0 (Swepub:umu)sora0001 |
700 | 1 | a Worthington, Jane4 aut |
700 | 1 | a Martin, Javier4 aut |
700 | 1 | a Eyre, Steve4 aut |
700 | 1 | a Klareskog, Larsu Karolinska Institutet4 aut |
700 | 1 | a Huizinga, Tom4 aut |
700 | 1 | a Chen, Wei-Min4 aut |
700 | 1 | a Onengut-Gumuscu, Suna4 aut |
700 | 1 | a Rich, Stephen S.4 aut |
700 | 1 | a Wray, Naomi R.4 aut |
700 | 1 | a Raychaudhuri, Soumya4 aut |
710 | 2 | a Umeå universitetb Reumatologi4 org |
773 | 0 | t Nature Geneticsd : Springer Science and Business Media LLCg 48:7, s. 803-+q 48:7<803-+x 1061-4036x 1546-1718 |
856 | 4 | u https://www.research.manchester.ac.uk/portal/files/36916062/Nature_Genetics_2016_Han_1.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-124226 |
856 | 4 8 | u https://doi.org/10.1038/ng.3572 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:133834123 |
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