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Durable carcinoembr...
Durable carcinoembryonic antigen (CEA)-specific humoral and cellular immune responses in colorectal carcinoma patients vaccinated with recombinant CEA and granulocyte/macrophage colony-stimulating factor.
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- Ullenhag, Gustav J (författare)
- Department of Oncology, Radiology and Clinical Immunology, Section of Oncology, Uppsala University Hospital, Uppsala, Sweden
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- Frödin, Jan-Erik (författare)
- Karolinska Institutet
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- Jeddi-Tehrani, Mahmood (författare)
- Karolinska Institutet
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- Strigård, Karin (författare)
- Karolinska Institutet
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- Eriksson, Emma (författare)
- Karolinska Institutet
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- Samanci, Ali (författare)
- Department of Oncology and CancerCentre Karolinska, Karolinska Hospital, Stockholm, Sweden
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- Choudhury, Aniruddha (författare)
- Karolinska Institutet
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- Nilsson, Bo (författare)
- Unit of Cancer Epidemiology, Institute of Oncology-Pathology, Radiumhemmet, Stockholm, Sweden
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- Rossmann, Eva D (författare)
- Department of Oncology and CancerCentre Karolinska, Karolinska Hospital, Stockholm, Sweden
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- Mosolits, Szilvia (författare)
- Department of Oncology and CancerCentre Karolinska, Karolinska Hospital, Stockholm, Sweden
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- Mellstedt, Håkan (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2004
- 2004
- Engelska.
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Ingår i: Clinical Cancer Research. - 1078-0432 .- 1557-3265. ; 10:10, s. 3273-3281
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
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- PURPOSE: Previous studies have indicated that carcinoembryonic antigen (CEA) might be a suitable immunotherapeutic target in colorectal carcinoma (CRC). The aim of the present study was to analyze the immunological and clinical effects of vaccination with CEA together with the adjuvant granulocyte/macrophage colony-stimulating factor (GM-CSF).EXPERIMENTAL DESIGN: Twenty-four resected CRC patients without macroscopic disease were immunized seven times with recombinant CEA at four different dose levels over a 12-month period. Half of the patients received GM-CSF (80 microg/day for 4 consecutive days) at each immunization. Patients were monitored immunologically for 36 months and clinically for 76 months. T-cell response was evaluated by a [(3)H]thymidine incorporation assay, and IgG response was determined by ELISA.RESULTS: Minor local side effects were common. All 12 patients (100%) in the GM-CSF group developed a CEA-specific T-cell as well as an IgG response. The corresponding figures in the CEA alone group were 9 of 12 (75%) and 8 of 12 (66%), respectively. GM-CSF significantly augmented the amplitude of the T-cell response and the IgG titers. No dose-response relationship was noted. The immune responses at 12 months persisted 24 months after the last vaccination. Anti-CEA IgG titers were associated with increased survival (P < 0.05), whereas standard prognostic factors had no relationship, with the exception of serum CEA value.CONCLUSIONS: Vaccination with recombinant CEA and GM-CSF appears to be a nontoxic regimen inducing potent and durable antigen-specific IgG and T-cell response. The results of this study justify more extensive trials with recombinant CEA protein for immunotherapy of CRC.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- CEA
- carcinoembryonic antigen
- CRC
- colorectal carcinoma
- GM-CSF
- granulocyte
- macrophage
- colony-stimulating factor
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Ullenhag, Gustav ...
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Frödin, Jan-Erik
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Jeddi-Tehrani, M ...
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Strigård, Karin
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Eriksson, Emma
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Samanci, Ali
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visa fler...
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Choudhury, Aniru ...
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Nilsson, Bo
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Rossmann, Eva D
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Mosolits, Szilvi ...
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Mellstedt, Håkan
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visa färre...
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och Klinisk medicin
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Umeå universitet
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Karolinska Institutet