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Gene expression cha...
Gene expression changes in tumor free tongue tissue adjacent to tongue squamous cell carcinoma
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- Boldrup, Linda (författare)
- Umeå universitet,Patologi,Umea Univ, Dept Med Biosci Pathol, SE-90185 Umea, Sweden.
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- Gu, Xiaolian (författare)
- Umeå universitet,Patologi,Umea Univ, Dept Med Biosci Pathol, SE-90185 Umea, Sweden.
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- Coates, Philip J. (författare)
- Masaryk Mem Canc Inst, RECAMO, Brno 65653, Czech Republic.
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- Norberg-Spaak, Lena (författare)
- Umeå universitet,Öron- näs- och halssjukdomar,Umea Univ, Dept Clin Sci ENT, SE-90185 Umea, Sweden.
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- Fåhraeus, Robin (författare)
- Umeå universitet,Patologi,RECAMO, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic; Institut de Génétique Moléculaire, Université Paris 7, Hôpital St. Louis, 75010 Paris, France,Umea Univ, Dept Med Biosci Pathol, SE-90185 Umea, Sweden.;Masaryk Mem Canc Inst, RECAMO, Brno 65653, Czech Republic.;Univ Paris 07, Hop St Louis, Inst Genet Mol, F-75010 Paris, France.
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- Laurell, Göran (författare)
- Uppsala universitet,Umeå universitet,Öron- näs- och halssjukdomar,Department of Surgical Sciences/ENT, Uppsala University, 752 36 Uppsala, Sweden,Öron-, näs- och halssjukdomar,Umea Univ, Dept Clin Sci ENT, SE-90185 Umea, Sweden
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- Wilms, Torben (författare)
- Umeå universitet,Öron- näs- och halssjukdomar,Umea Univ, Dept Clin Sci ENT, SE-90185 Umea, Sweden.
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- Nylander, Karin (författare)
- Umeå universitet,Patologi,Umea Univ, Dept Med Biosci Pathol, SE-90185 Umea, Sweden.
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(creator_code:org_t)
- 2016-12-27
- 2017
- Engelska.
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Ingår i: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 8:12, s. 19389-19402
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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http://www.oncotarge...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Due to the high frequency of loco-regional recurrences, which could be explained by changes in the field surrounding the tumor, patients with squamous cell carcinoma of head and neck show poor survival. Here we identified a total of 554 genes as dysregulated in clinically tumor free tongue tissue in patients with tongue tumors when compared to healthy control tongue tissue. Among the top dysregulated genes when comparing control and tumor free tissue were those involved in apoptosis (CIDEC, MUC1, ZBTB16, PRNP, ECT2), immune response (IFI27) and differentiation (KRT36). Data suggest that these are important findings which can aid in earlier diagnosis of tumor development, a relapse or a novel squamous cell carcinoma of the tongue, in the absence of histological signs of a tumor.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- tongue cancer
- RNA expression
- field cancerization
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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