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Inflammatory Cytoki...
Inflammatory Cytokines and Lung Cancer Risk in 3 Prospective Studies
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Brenner, Darren R. (författare)
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Fanidi, Anouar (författare)
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- Grankvist, Kjell (författare)
- Umeå universitet,Klinisk kemi
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Muller, David C. (författare)
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Brennan, Paul (författare)
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Manjer, Jonas (författare)
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Byrnes, Graham (författare)
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Hodge, Allison (författare)
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Severi, Gianluca (författare)
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Giles, Graham G. (författare)
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- Johansson, Mikael (författare)
- Umeå universitet,Institutionen för strålningsvetenskaper
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Johansson, Mattias (författare)
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(creator_code:org_t)
- 2016-12-20
- 2017
- Engelska.
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Ingår i: American Journal of Epidemiology. - : OXFORD UNIV PRESS INC. - 0002-9262 .- 1476-6256. ; 185:2, s. 86-95
- Relaterad länk:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- To further investigate the role of inflammation in lung carcinogenesis, we evaluated associations between proinflammatory cytokines and lung cancer risk. We conducted a case-control study nested within 3 prospective cohort studies-the Melbourne Collaborative Cohort Study (1990-1994), the Malm Diet and Cancer Study (1991-1996), and the Northern Sweden Health and Disease Study (initiated in 1985)-involving 807 incident lung cancer cases and 807 smoking-matched controls. Conditional logistic regression models adjusting for serum cotinine concentrations were used to estimate odds ratios for lung cancer risk associated with concentrations of interleukin (IL)-1 beta, IL-2, IL-6, IL-8, IL-10, IL-12, interferon., tumor necrosis factor a, and granulocyte-macrophage colony-stimulating factor. We observed a higher lung cancer risk for participants with elevated concentrations of IL-6 and IL-8. These associations seemed to be stronger among former smokers (for fourth quartile vs. first quartile, odds ratio (OR) = 2.70, 95% confidence interval (CI): 1.55, 4.70) and current smokers (OR = 1.99, 95% CI: 1.15, 3.44) for IL-6 and among former smokers (OR = 2.83, 95% CI: 1.18, 6.75) and current smokers (OR = 1.30, 95% CI: 0.69, 2.44) for IL-8. No notable associations were observed among never smokers. Risk associations with IL-6 and IL-8 were observed for blood samples taken close to diagnosis (< 5 years) as well as more than 15 years postdiagnosis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- cohort studies
- cytokines
- inflammation
- lung neoplasms
- risk factors
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Brenner, Darren ...
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Fanidi, Anouar
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Grankvist, Kjell
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Muller, David C.
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Brennan, Paul
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Manjer, Jonas
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visa fler...
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Byrnes, Graham
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Hodge, Allison
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Severi, Gianluca
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Giles, Graham G.
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Johansson, Mikae ...
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Johansson, Matti ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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American Journal ...
- Av lärosätet
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Umeå universitet