Sökning: onr:"swepub:oai:DiVA.org:umu-133518" > Unity in defence :
Fältnamn | Indikatorer | Metadata |
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000 | 05459naa a2200781 4500 | |
001 | oai:DiVA.org:umu-133518 | |
003 | SwePub | |
008 | 170520s2017 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1335182 URI |
024 | 7 | a https://doi.org/10.1186/s12864-017-3597-62 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Doublet, Vincent4 aut |
245 | 1 0 | a Unity in defence :b honeybee workers exhibit conserved molecular responses to diverse pathogens |
264 | c 2017-03-02 | |
264 | 1 | b BIOMED CENTRAL LTD,c 2017 |
338 | a electronic2 rdacarrier | |
500 | a Errata BMC Genomics 2017 18:256 https://doi.org/10.1186/s12864-017-3624-7 | |
520 | a Background: Organisms typically face infection by diverse pathogens, and hosts are thought to have developed specific responses to each type of pathogen they encounter. The advent of transcriptomics now makes it possible to test this hypothesis and compare host gene expression responses to multiple pathogens at a genome-wide scale. Here, we performed a meta-analysis of multiple published and new transcriptomes using a newly developed bioinformatics approach that filters genes based on their expression profile across datasets. Thereby, we identified common and unique molecular responses of a model host species, the honey bee (Apis mellifera), to its major pathogens and parasites: the Microsporidia Nosema apis and Nosema ceranae, RNA viruses, and the ectoparasitic mite Varroa destructor, which transmits viruses.Results: We identified a common suite of genes and conserved molecular pathways that respond to all investigated pathogens, a result that suggests a commonality in response mechanisms to diverse pathogens. We found that genes differentially expressed after infection exhibit a higher evolutionary rate than non-differentially expressed genes. Using our new bioinformatics approach, we unveiled additional pathogen-specific responses of honey bees; we found that apoptosis appeared to be an important response following microsporidian infection, while genes from the immune signalling pathways, Toll and Imd, were differentially expressed after Varroa/virus infection. Finally, we applied our bioinformatics approach and generated a gene co-expression network to identify highly connected (hub) genes that may represent important mediators and regulators of anti-pathogen responses.Conclusions: Our meta-analysis generated a comprehensive overview of the host metabolic and other biological processes that mediate interactions between insects and their pathogens. We identified key host genes and pathways that respond to phylogenetically diverse pathogens, representing an important source for future functional studies as well as offering new routes to identify or generate pathogen resilient honey bee stocks. The statistical and bioinformatics approaches that were developed for this study are broadly applicable to synthesize information across transcriptomic datasets. These approaches will likely have utility in addressing a variety of biological questions. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
653 | a Apis mellifera | |
653 | a Nosema | |
653 | a Varroa destructor | |
653 | a DWV | |
653 | a IAPV | |
653 | a RNA virus | |
653 | a Meta-analysis | |
653 | a Transcriptomics | |
653 | a Co-expression network | |
653 | a Immunity | |
700 | 1 | a Poeschl, Yvonne4 aut |
700 | 1 | a Gogol-Doering, Andreas4 aut |
700 | 1 | a Alaux, Cedric4 aut |
700 | 1 | a Annoscia, Desiderato4 aut |
700 | 1 | a Aurori, Christian4 aut |
700 | 1 | a Barribeau, Seth M.4 aut |
700 | 1 | a Bedoya-Reina, Oscar C.4 aut |
700 | 1 | a Brown, Mark J. F.4 aut |
700 | 1 | a Bull, James C.4 aut |
700 | 1 | a Flenniken, Michelle L.4 aut |
700 | 1 | a Galbraith, David A.4 aut |
700 | 1 | a Genersch, Elke4 aut |
700 | 1 | a Gisder, Sebastian4 aut |
700 | 1 | a Grosse, Ivo4 aut |
700 | 1 | a Holt, Holly L.4 aut |
700 | 1 | a Hultmark, Danu Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)4 aut0 (Swepub:umu)dahu0001 |
700 | 1 | a Lattorff, H. Michael G.4 aut |
700 | 1 | a Le Conte, Yves4 aut |
700 | 1 | a Manfredini, Fabio4 aut |
700 | 1 | a McMahon, Dino P.4 aut |
700 | 1 | a Moritz, Robin F. A.4 aut |
700 | 1 | a Nazzi, Francesco4 aut |
700 | 1 | a Nino, Elina L.4 aut |
700 | 1 | a Nowick, Katja4 aut |
700 | 1 | a van Rij, Ronald P.4 aut |
700 | 1 | a Paxton, Robert J.4 aut |
700 | 1 | a Grozinger, Christina M.4 aut |
710 | 2 | a Umeå universitetb Institutionen för molekylärbiologi (Medicinska fakulteten)4 org |
773 | 0 | t BMC Genomicsd : BIOMED CENTRAL LTDg 18q 18x 1471-2164 |
856 | 4 | u https://doi.org/10.1186/s12864-017-3597-6y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1096962/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://bmcgenomics.biomedcentral.com/track/pdf/10.1186/s12864-017-3597-6 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-133518 |
856 | 4 8 | u https://doi.org/10.1186/s12864-017-3597-6 |
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