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Spatial and quantit...
Spatial and quantitative datasets of the pancreatic beta-cell mass distribution in lean and obese mice
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- Parween, Saba (författare)
- Umeå universitet,Umeå centrum för molekylär medicin (UCMM)
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- Eriksson, Maria (författare)
- Umeå universitet,Umeå centrum för molekylär medicin (UCMM)
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- Nord, Christoffer (författare)
- Umeå universitet,Umeå centrum för molekylär medicin (UCMM)
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- Kostromina, Elena (författare)
- Umeå universitet,Umeå centrum för molekylär medicin (UCMM)
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- Ahlgren, Ulf (författare)
- Umeå universitet,Umeå centrum för molekylär medicin (UCMM)
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(creator_code:org_t)
- 2017-03-14
- 2017
- Engelska.
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Ingår i: Scientific Data. - : Springer Science and Business Media LLC. - 2052-4463. ; 4
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- A detailed understanding of pancreatic β-cell mass distribution is a key element to fully appreciate the pathophysiology of models of diabetes and metabolic stress. Commonly, such assessments have been performed by stereological approaches that rely on the extrapolation of two-dimensional data and provide very limited topological information. We present ex vivo optical tomographic data sets of the full β-cell mass distribution in cohorts of obese ob/ob mice and their lean controls, together with information about individual islet β-cell volumes, their three-dimensional coordinates and shape throughout the volume of the pancreas between 4 and 52 weeks of age. These data sets offer the currently most comprehensive public record of the β-cell mass distribution in the mouse. As such, they may serve as a quantitative and topological reference for the planning of a variety of in vivo or ex vivo experiments including computational modelling and statistical analyses. By shedding light on intra- and inter-lobular variations in β-cell mass distribution, they further provide a powerful tool for the planning of stereological sampling assessments.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)
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