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Spatial and quantit...
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Parween, SabaUmeå universitet,Umeå centrum för molekylär medicin (UCMM)
(författare)
Spatial and quantitative datasets of the pancreatic beta-cell mass distribution in lean and obese mice
- Artikel/kapitelEngelska2017
Förlag, utgivningsår, omfång ...
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2017-03-14
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Springer Science and Business Media LLC,2017
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electronicrdacarrier
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LIBRIS-ID:oai:DiVA.org:umu-133764
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-133764URI
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https://doi.org/10.1038/sdata.2017.31DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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A detailed understanding of pancreatic β-cell mass distribution is a key element to fully appreciate the pathophysiology of models of diabetes and metabolic stress. Commonly, such assessments have been performed by stereological approaches that rely on the extrapolation of two-dimensional data and provide very limited topological information. We present ex vivo optical tomographic data sets of the full β-cell mass distribution in cohorts of obese ob/ob mice and their lean controls, together with information about individual islet β-cell volumes, their three-dimensional coordinates and shape throughout the volume of the pancreas between 4 and 52 weeks of age. These data sets offer the currently most comprehensive public record of the β-cell mass distribution in the mouse. As such, they may serve as a quantitative and topological reference for the planning of a variety of in vivo or ex vivo experiments including computational modelling and statistical analyses. By shedding light on intra- and inter-lobular variations in β-cell mass distribution, they further provide a powerful tool for the planning of stereological sampling assessments.
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Eriksson, MariaUmeå universitet,Umeå centrum för molekylär medicin (UCMM)(Swepub:umu)maer0057
(författare)
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Nord, ChristofferUmeå universitet,Umeå centrum för molekylär medicin (UCMM)(Swepub:umu)chsv0004
(författare)
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Kostromina, ElenaUmeå universitet,Umeå centrum för molekylär medicin (UCMM)(Swepub:umu)elko0010
(författare)
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Ahlgren, UlfUmeå universitet,Umeå centrum för molekylär medicin (UCMM)(Swepub:umu)ulah0001
(författare)
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Umeå universitetUmeå centrum för molekylär medicin (UCMM)
(creator_code:org_t)
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Ingår i:Scientific Data: Springer Science and Business Media LLC42052-4463
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