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Initial performance...
Initial performance studies of a wearable brain positron emission tomography camera based on autonomous thin-film digital Geiger avalanche photodiode arrays
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- Schmidtlein, Charles R. (författare)
- Memorial Sloan Kettering Cancer Center
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- Turner, James N. (författare)
- State University of New York at Binghamton
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- Thompson, Michael O. (författare)
- Cornell University
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- Mandal, Krishna C. (författare)
- University of South Carolina
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- Häggström, Ida (författare)
- Memorial Sloan Kettering Cancer Center
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- Zhang, Jiahan (författare)
- State University of New York Upstate Medical University
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- Humm, John L. (författare)
- Memorial Sloan Kettering Cancer Center
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- Feiglin, David H. (författare)
- State University of New York Upstate Medical University
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- Krol, Andrzej (författare)
- State University of New York Upstate Medical University
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(creator_code:org_t)
- SPIE - International Society for Optical Engineering, 2017
- 2017
- Engelska.
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Ingår i: Journal of Medical Imaging. - : SPIE - International Society for Optical Engineering. - 2329-4302 .- 2329-4310. ; 4:1
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Using analytical and Monte Carlo modeling, we explored performance of a lightweight wearable helmet-shaped brain positron emission tomography (PET), or BET camera, based on thin-film digital Geiger avalanche photodiode arrays with Lutetium-yttrium oxyorthosilicate (LYSO) or LaBr3 scintillators for imaging in vivo human brain function of freely moving and acting subjects. We investigated a spherical cap BET and cylindrical brain PET (CYL) geometries with 250-mm diameter. We also considered a clinical whole-body (WB) LYSO PET/CT scanner. The simulated energy resolutions were 10.8% (LYSO) and 3.3% (LaBr3), and the coincidence window was set at 2 ns. The brain was simulated as a water sphere of uniform F-18 activity with a radius of 100 mm. We found that BET achieved >40% better noise equivalent count (NEC) performance relative to the CYL and >800% than WB. For 10-mm-thick LaBr3 equivalent mass systems, LYSO (7-mm thick) had similar to 40% higher NEC than LaBr3. We found that 1 x 1 x 3 mm scintillator crystals achieved similar to 1.1 mm full-width-half-maximum spatial resolution without parallax errors. Additionally, our simulations showed that LYSO generally outperformed LaBr3 for NEC unless the timing resolution for LaBr3 was considerably smaller than that presently used for LYSO, i.e., well below 300 ps.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk apparatteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Equipment Engineering (hsv//eng)
Nyckelord
- Positron emission tomography
- Sensors
- Scintillators
- Brain
- Photons
- Imaging systems
- Neuroimaging
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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