Sökning: onr:"swepub:oai:DiVA.org:umu-13553" > Multivariate design...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 02893naa a2200361 4500 | |
001 | oai:DiVA.org:umu-13553 | |
003 | SwePub | |
008 | 070511s2005 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-135532 URI |
024 | 7 | a https://doi.org/10.1021/jm040818l2 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Larsson, Andreasu Umeå universitet,Kemiska institutionen4 aut0 (Swepub:umu)anslan95 |
245 | 1 0 | a Multivariate design, synthesis, and biological evaluation of peptide inhibitors of FimC/FimH protein-protein interactions in uropathogenic Escherichia coli |
264 | c 2005-02-01 | |
264 | 1 | b American Chemical Society (ACS),c 2005 |
338 | a print2 rdacarrier | |
520 | a A peptide library targeting protein-protein interactions crucial for pilus assembly in Gram negative bacteria has been designed using statistical molecular design. A nonamer peptide scaffold was used, with seven positions being varied. The selection was performed in the building block space, and previously known structure-activity data were included in the design procedure. This resulted in a heavily reduced library consisting of 32 peptides which was prepared by solid-phase synthesis. The ability of the peptides to inhibit the protein-protein interaction between the periplasmic chaperone FimC and the pilus adhesin FimH was then determined in an ELISA. Novel peptides with the capability to inhibit the FimC/FimH protein(-)protein interaction to the same extent as the native FimC peptides were discovered. Multivariate QSAR studies of the response in the ELISA gave valuable information on the properties of amino acids which were preferred at the seven positions in the nonamer scaffold. This information can be used in attempts to develop optimized peptides and peptidomimetics that inhibit pilus assembly in pathogenic bacteria. | |
650 | 7 | a NATURVETENSKAPx Kemi0 (SwePub)1042 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Chemical Sciences0 (SwePub)1042 hsv//eng |
700 | 1 | a Johansson, Susanne M. C.u Umeå universitet,Kemiska institutionen4 aut |
700 | 1 | a Pinkner, Jerome S.4 aut |
700 | 1 | a Hultgren, Scott J.4 aut |
700 | 1 | a Almqvist, Fredriku Umeå universitet,Kemiska institutionen4 aut0 (Swepub:umu)fral0001 |
700 | 1 | a Kihlberg, Janu Umeå universitet,Kemiska institutionen4 aut0 (Swepub:umu)jaki0001 |
700 | 1 | a Linusson, Annau Umeå universitet,Kemiska institutionen4 aut0 (Swepub:umu)analin99 |
710 | 2 | a Umeå universitetb Kemiska institutionen4 org |
773 | 0 | t Journal of Medicinal Chemistryd : American Chemical Society (ACS)g 48:4, s. 935-945q 48:4<935-945x 0022-2623x 1520-4804 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-13553 |
856 | 4 8 | u https://doi.org/10.1021/jm040818l |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy