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Motion corrected DW...
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Skorpil, MikaelUmeå universitet,Institutionen för strålningsvetenskaper,Department of Radiology, Uppsala University Hospital, Uppsala, Sweden,Umeå Univ, Dept Radiat Sci, Umeå, Sweden.
(författare)
Motion corrected DWI with integrated T2-mapping for simultaneous estimation of ADC, T2-relaxation and perfusion in prostate cancer
- Artikel/kapitelEngelska2017
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Elsevier,2017
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LIBRIS-ID:oai:DiVA.org:umu-136049
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-136049URI
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https://doi.org/10.1016/j.mri.2017.03.003DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-324241URI
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Språk:engelska
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Sammanfattning på:engelska
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Objective: Multiparametric magnetic resonance imaging (MRI) and PI-RADS (Prostate Imaging - Reporting and Data System) has become the standard to determine a probability score for a lesion being a clinically significant prostate cancer. T2-weighted and diffusion-weighted imaging (DWI) are essential in PI-RADS, depending partly on visual assessment of signal intensity, while dynamic-contrast enhanced imaging is less important. To decrease inter-rater variability and further standardize image evaluation, complementary objective measures are in need. Methods: We here demonstrate a sequence enabling simultaneous quantification of apparent diffusion coefficient (ADC) and T2-relaxation, as well as calculation of the perfusion fraction f from low b-value intravoxel incoherent motion data. Expandable wait pulses were added to a FOCUS DW SE-EPI sequence, allowing the effective echo time to change at run time. To calculate both ADC and f, b-values 200 s/mm(2) and 600 s/mm(2) were chosen, and for T2-estimation 6 echo times between 64.9 ms and 114.9 ms were used. Results: Three patients with prostate cancer were examined and all had significantly decreased ADC and T2 values, while f was significantly increased in 2 of 3 tumors. T2 maps obtained in phantom measurements and in a healthy volunteer were compared to T2 maps from a SE sequence with consecutive scans, showing good agreement. In addition, a motion correction procedure was implemented to reduce the effects of prostate motion, which improved T2-estimation. Conclusions: This sequence could potentially enable more objective tumor grading, and decrease the inter-rater variability in the PI-RADS classification.
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Brynolfsson, PatrikUmeå universitet,Institutionen för strålningsvetenskaper,Umeå Univ, Dept Radiat Sci, Umeå, Sweden.(Swepub:umu)pakbon02
(författare)
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Engström, M.GE Healthcare, Appl Sci Lab, Uppsala, Sweden.
(författare)
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Umeå universitetInstitutionen för strålningsvetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Magnetic Resonance Imaging: Elsevier39, s. 162-1670730-725X1873-5894
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