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Human hantavirus in...
Human hantavirus infection elicits pronounced redistribution of mononuclear phagocytes in peripheral blood and airways
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Scholz, Saskia (författare)
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Baharom, Faezzah (författare)
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- Rankin, Gregory (författare)
- Umeå universitet,Medicin
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- Maleki, Kimia T. (författare)
- Karolinska Institutet
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Gupta, Shawon (författare)
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Vangeti, Sindhu (författare)
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- Pourazar, Jamshid (författare)
- Umeå universitet,Medicin
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- Discacciati, Andrea (författare)
- Karolinska Institutet
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- Höijer, Jonas (författare)
- Karolinska Institutet
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- Bottai, Matteo (författare)
- Karolinska Institutet
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- Björkström, Niklas K. (författare)
- Karolinska Institutet
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- Rasmuson, Johan, 1977- (författare)
- Umeå universitet,Infektionssjukdomar
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- Evander, Magnus (författare)
- Umeå universitet,Virologi
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- Blomberg, Anders (författare)
- Umeå universitet,Medicin
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- Ljunggren, Hans-Gustaf (författare)
- Karolinska Institutet
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- Klingström, Jonas (författare)
- Karolinska Institutet
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- Ahlm, Clas (författare)
- Umeå universitet,Infektionssjukdomar
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- Smed-Sörensen, Anna (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2017-06-22
- 2017
- Engelska.
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Ingår i: PLoS Pathogens. - : Public library science. - 1553-7366 .- 1553-7374. ; 13:6
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://journals.plo...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
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- Hantaviruses infect humans via inhalation of virus-contaminated rodent excreta. Infection can cause severe disease with up to 40% mortality depending on the viral strain. The virus primarily targets the vascular endothelium without direct cytopathic effects. Instead, exaggerated immune responses may inadvertently contribute to disease development. Mononuclear phagocytes (MNPs), including monocytes and dendritic cells (DCs), orchestrate the adaptive immune responses. Since hantaviruses are transmitted via inhalation, studying immunological events in the airways is of importance to understand the processes leading to immunopathogenesis. Here, we studied 17 patients infected with Puumala virus that causes a mild form of hemorrhagic fever with renal syndrome (HFRS). Bronchial biopsies as well as longitudinal blood draws were obtained from the patients. During the acute stage of disease, a significant influx of MNPs expressing HLA-DR, CD11c or CD123 was detected in the patients' bronchial tissue. In parallel, absolute numbers of MNPs were dramatically reduced in peripheral blood, coinciding with viremia. Expression of CCR7 on the remaining MNPs in blood suggested migration to peripheral and/or lymphoid tissues. Numbers of MNPs in blood subsequently normalized during the convalescent phase of the disease when viral RNA was no longer detectable in plasma. Finally, we exposed blood MNPs in vitro to Puumala virus, and demonstrated an induction of CCR7 expression on MNPs. In conclusion, the present study shows a marked redistribution of blood MNPs to the airways during acute hantavirus disease, a process that may underlie the local immune activation and contribute to immunopathogenesis in hantavirus-infected patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Scholz, Saskia
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Baharom, Faezzah
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Rankin, Gregory
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Maleki, Kimia T.
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Gupta, Shawon
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Vangeti, Sindhu
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visa fler...
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Pourazar, Jamshi ...
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Discacciati, And ...
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Höijer, Jonas
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Bottai, Matteo
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Björkström, Nikl ...
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Rasmuson, Johan, ...
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Evander, Magnus
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Blomberg, Anders
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Ljunggren, Hans- ...
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Klingström, Jona ...
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Ahlm, Clas
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Smed-Sörensen, A ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Mikrobiologi ino ...
- Artiklar i publikationen
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PLoS Pathogens
- Av lärosätet
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Umeå universitet
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Karolinska Institutet