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Sökning: onr:"swepub:oai:DiVA.org:umu-138050" > Plasma levels of th...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004297naa a2200469 4500
001oai:DiVA.org:umu-138050
003SwePub
008170811s2017 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1380502 URI
0247 a https://doi.org/10.1016/j.plefa.2017.04.0052 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Gouveia-Figueira, Sandrau Umeå universitet,Kemiska institutionen4 aut0 (Swepub:umu)sago0010
2451 0a Plasma levels of the endocannabinoid anandamide, related N-acylethanolamines and linoleic acid-derived oxylipins in patients with migraine
264 1b Elsevier BV,c 2017
338 a print2 rdacarrier
520 a There is evidence that patients with migraine have deficient levels of the endogenous cannabinoid receptor ligand anandamide (AEA). It is not known, however, if this is a localised or generalised phenomenon. In the present study, levels of AEA, related N-acylethanolamines (NAEs) and linoleic acid-derived oxylipins have been measured in the blood of 26 healthy women and 38 women with migraine (26 with aura, 12 without aura) who were matched for age and body-mass index. Blood samples were taken on two occasions: the first sample near the start of the menstrual cycle (when present) and the second approximately fourteen days later. For a subset of migraine patients, two additional blood samples were taken, one during a migraine attack and one approximately 1 month later (to be at the same stage in the menstrual cycle, when present). NAEs and oxylipins were measured by liquid chromatography coupled to mass spectrometry. Twenty-nine lipids were quantified, of which 16 were found to have a high reproducibility of measurement. There were no significant differences in the levels of AEA, the related NAEs stearoylethanolamide and oleoylethanolamide or any of the nine linoleic acid derived oxylipins measured either between migraine patients with vs. without aura, or between controls and migraine patients (after stratification to take into account whether or not the individuals had regular menstruation cycles) in either of the first two samples. Levels of linoleoylethanolamide were lower in the patients with vs. without aura on the second sample but not in the first sample, but the biological importance of this fording is unclear. Due to time-dependent increases in their concentrations ex vivo prior to centrifugation, AEA and oleoylethanolamide levels in the samples collected during migraine attacks were not analysed, but for the other fourteen lipids, there were no significant differences in plasma concentrations during migraine vs. one month later. It is concluded that migraine is not associated with a generalised (as opposed to localised) deficiency in these lipids.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Annan klinisk medicin0 (SwePub)302992 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Other Clinical Medicine0 (SwePub)302992 hsv//eng
653 a Migraine
653 a Endocannabinoid
653 a Anandamide
653 a Stearoylethanolamide
653 a Linoleoylethanolamide
653 a Oxylipin
653 a 9- droxy-10E
653 a 12Z-octadecadienoic acid
653 a Blood plasma
7001 a Goldin, Kristina4 aut
7001 a Hashemian, Sanaz A.u Umeå universitet,Farmakologi4 aut0 (Swepub:umu)saal0023
7001 a Lindberg, Agneta4 aut
7001 a Persson, Monica4 aut
7001 a Nording, Malin L.u Umeå universitet,Kemiska institutionen4 aut0 (Swepub:umu)mano0003
7001 a Laurell, Katarinau Umeå universitet,Klinisk neurovetenskap,Department of Neurology, Östersund Hospital, SE-83183 Östersund, Sweden4 aut0 (Swepub:umu)kala0094
7001 a Fowler, Christopher J.u Umeå universitet,Farmakologi4 aut0 (Swepub:umu)chfo0001
7102 a Umeå universitetb Kemiska institutionen4 org
7730 t Prostaglandins, Leukotrienes and Essential Fatty Acidsd : Elsevier BVg 120, s. 15-24q 120<15-24x 0952-3278x 1532-2823
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-138050
8564 8u https://doi.org/10.1016/j.plefa.2017.04.005

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