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Left atrial appenda...
Left atrial appendage occlusion versus standard medical care in patients with atrial fibrillation and intracerebral haemorrhage : a propensity score-matched follow-up study
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Nielsen-Kudsk, Jens Erik (författare)
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Johnsen, Soren Paaske (författare)
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- Wester, Per (författare)
- Karolinska Institutet,Umeå universitet,Medicin,Karolinska Inst, Danderyd, Sweden
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Damgaard, Dorte (författare)
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Airaksinen, Juhani (författare)
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Lund, Juha (författare)
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De Backer, Ole (författare)
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Pakarinen, Sami (författare)
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Odenstedt, Jacob (författare)
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Vikman, Saila (författare)
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- Settergren, Magnus (författare)
- Karolinska Institutet
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Kongstad, Ole (författare)
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- Rosenqvist, Marten (författare)
- Karolinska Institutet
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Krieger, Derk W. (författare)
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(creator_code:org_t)
- EUROPA EDITION, 2017
- 2017
- Engelska.
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Ingår i: EuroIntervention. - : EUROPA EDITION. - 1774-024X .- 1969-6213. ; 13:3, s. 371-378
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.4...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Aims: The aim of this study was to investigate the prognosis in patients with atrial fibrillation (AF) and intracerebral haemorrhage (ICH) having a left atrial appendage occlusion (LAAO) versus patients receiving standard medical therapy. Methods and results: A total of 151 patients from the Nordic countries with AF and previous ICH who underwent LAAO using the AMPLATZER Cardiac Plug or the AMPLATZER AMULET were compared to a propensity score-matched group of 151 patients receiving standard medical therapy. The two groups were matched so that their risks for stroke and bleeding were similar (CHA2DS2-VASc and HAS-BLED scores). The standard care patients were identified from the Danish Stroke Registry among 787 patients with AF and ICH. The primary endpoint was a composite of all-cause mortality, ischaemic stroke and major bleeding. Patients with AF and a prior ICH treated with LAAO had a lower risk of the composite outcome as compared to patients treated with standard medical care (events/1,000 years [95% confidence interval]: 53.3 [44.3-64.1] vs. 366.7 [298.2-450.9]; hazard ratio 0.16 [0.07-0.37]). Conclusions: LAAO is suggested to be of major clinical benefit in AF patients having sustained an ICH. These results have to be confirmed in a randomised clinical trial.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- atrial fibrillation
- clinical research
- left atrial appendage (LAA)
- closure
- stroke
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Nielsen-Kudsk, J ...
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Johnsen, Soren P ...
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Wester, Per
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Damgaard, Dorte
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Airaksinen, Juha ...
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Lund, Juha
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visa fler...
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De Backer, Ole
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Pakarinen, Sami
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Odenstedt, Jacob
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Vikman, Saila
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Settergren, Magn ...
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Kongstad, Ole
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Rosenqvist, Mart ...
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Krieger, Derk W.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
- Artiklar i publikationen
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EuroIntervention
- Av lärosätet
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Umeå universitet
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Karolinska Institutet