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Parietal cortex act...
Parietal cortex activation predicts memory decline in apolipoprotein E-epsilon 4 carriers
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- Lind, Johanna (författare)
- Karolinska Institutet
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- Ingvar, Martin (författare)
- Karolinska Institutet
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- Persson, Jonas, 1971- (författare)
- Umeå universitet,Institutionen för psykologi
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- Sleegers, Kristel (författare)
- Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerp, Belgium
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- Van Broeckhoven, Christine (författare)
- Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerp, Belgium
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- Adolfsson, Rolf (författare)
- Umeå universitet,Psykiatri
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- Nilsson, Lars-Göran, 1944- (författare)
- Department of Psychology, Stockholm University, Stockholm
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- Nyberg, Lars, 1966- (författare)
- Umeå universitet,Institutionen för psykologi
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(creator_code:org_t)
- Oxford : Rapid Communications of Oxford, 2006
- 2006
- Engelska.
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Ingår i: NeuroReport. - Oxford : Rapid Communications of Oxford. - 0959-4965 .- 1473-558X. ; 17:16, s. 1683-1686
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Apolipoprotein E-[varepsilon]4 is the main known genetic risk factor for Alzheimer's disease. Functional abnormalities in the parietal cortex have been reported for Alzheimer's disease patients and also for those at risk. Hence, a critical question is whether measurements of parietal cortex integrity may predict negative outcome among at-risk persons. We studied nondementedapolipoprotein E-[varepsilon]4 carriers and found a significant relationship between parietal blood-oxygen-level-dependent functional magnetic resonance imaging response during a word categorization task and subsequent episodic memory performance. Thus, the results show that parietal cortex alterations predict memory decline in nondemented apolipoprotein E-[varepsilon]4 carriers, and hence likely progression to Alzheimer's disease.
Nyckelord
- Alzheimer's disease
- apolipoprotein E
- functional magnetic resonance imaging
- memory
- parietal cortex
- MEDICINE
- MEDICIN
- medicin
- Medicine
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Lind, Johanna
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Ingvar, Martin
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Persson, Jonas, ...
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Sleegers, Kriste ...
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Van Broeckhoven, ...
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Adolfsson, Rolf
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visa fler...
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Nilsson, Lars-Gö ...
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Nyberg, Lars, 19 ...
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- Artiklar i publikationen
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NeuroReport
- Av lärosätet
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Umeå universitet
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Karolinska Institutet