Sökning: onr:"swepub:oai:DiVA.org:umu-142454" > Association between...
Fältnamn | Indikatorer | Metadata |
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000 | 09232naa a2201141 4500 | |
001 | oai:DiVA.org:umu-142454 | |
003 | SwePub | |
008 | 171204s2017 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:8803677f-9b52-4741-817e-d6716d469233 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1424542 URI |
024 | 7 | a https://doi.org/10.1186/s12916-017-0968-42 DOI |
024 | 7 | a https://lup.lub.lu.se/record/8803677f-9b52-4741-817e-d6716d4692332 URI |
040 | a (SwePub)umud (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Zheng, Ju-Shengu University of Cambridge4 aut |
245 | 1 0 | a Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries :b a cross-sectional analysis in the EPIC-InterAct study |
264 | c 2017-11-17 | |
264 | 1 | b BioMed Central,c 2017 |
338 | a electronic2 rdacarrier | |
520 | a Background: Accumulating evidence suggests that individual circulating saturated fatty acids (SFAs) are heterogeneous in their associations with cardio-metabolic diseases, but evidence about associations of SFAs with metabolic markers of different pathogenic pathways is limited. We aimed to examine the associations between plasma phospholipid SFAs and the metabolic markers of lipid, hepatic, glycaemic and inflammation pathways. Methods: We measured nine individual plasma phospholipid SFAs and derived three SFA groups (odd-chain: C15:0 + C17:0, even-chain: C14:0 + C16:0 + C18:0, and very-long-chain: C20:0 + C22:0 + C23:0 + C24:0) in individuals from the subcohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study across eight European countries. Using linear regression in 15,919 subcohort members, adjusted for potential confounders and corrected for multiple testing, we examined cross-sectional associations of SFAs with 13 metabolic markers. Multiplicative interactions of the three SFA groups with pre-specified factors, including body mass index (BMI) and alcohol consumption, were tested. Results: Higher levels of odd-chain SFA group were associated with lower levels of major lipids (total cholesterol (TC), triglycerides, apolipoprotein A-1 (ApoA1), apolipoprotein B (ApoB)) and hepatic markers (alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyl transferase (GGT)). Higher even-chain SFA group levels were associated with higher levels of low-density lipoprotein cholesterol (LDL-C), TC/high-density lipoprotein cholesterol (HDL-C) ratio, triglycerides, ApoB, ApoB/A1 ratio, ALT, AST, GGT and CRP, and lower levels of HDL-C and ApoA1. Very-long-chain SFA group levels showed inverse associations with triglycerides, ApoA1 and GGT, and positive associations with TC, LDL-C, TC/HDL-C, ApoB and ApoB/A1. Associations were generally stronger at higher levels of BMI or alcohol consumption. Conclusions: Subtypes of SFAs are associated in a differential way with metabolic markers of lipid metabolism, liver function and chronic inflammation, suggesting that odd-chain SFAs are associated with lower metabolic risk and even-chain SFAs with adverse metabolic risk, whereas mixed findings were obtained for very-long-chain SFAs. The clinical and biochemical implications of these findings may vary by adiposity and alcohol intake. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
653 | a Saturated fatty acids | |
653 | a Odd-chain | |
653 | a Even-chain | |
653 | a Very-long-chain | |
653 | a Metabolic markers | |
653 | a Lipids | |
653 | a Hepatic | |
653 | a ycaemic | |
653 | a Inflammation | |
653 | a Even-chain | |
653 | a Glycaemic | |
653 | a Hepatic | |
653 | a Inflammation | |
653 | a Lipids | |
653 | a Metabolic markers | |
653 | a Odd-chain | |
653 | a Saturated fatty acids | |
653 | a Very-long-chain | |
700 | 1 | a Sharp, Stephen J.u University of Cambridge4 aut |
700 | 1 | a Imamura, Fumiakiu University of Cambridge4 aut |
700 | 1 | a Koulman, Albertu MRC Human Nutrition Research,NIHR Cambridge Biomedical Research Centre4 aut |
700 | 1 | a Schulze, Matthias B.u German Institute of Human Nutrition4 aut |
700 | 1 | a Ye, Zhengu University of Cambridge4 aut |
700 | 1 | a Griffin, Julesu University of Cambridge4 aut |
700 | 1 | a Guevara, Marcelau CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)4 aut |
700 | 1 | a María Huerta, Joséu CIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council4 aut |
700 | 1 | a Kröger, Janineu German Institute of Human Nutrition4 aut |
700 | 1 | a Sluijs, Ivonneu University Medical Center Utrecht4 aut |
700 | 1 | a Agudo, Antoniou Bellvitge University Hospital-IDIBELL4 aut |
700 | 1 | a Barricarte, Aureliou Health Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP)4 aut |
700 | 1 | a Boeing, Heineru German Institute of Human Nutrition4 aut |
700 | 1 | a Colorado-Yohar, Sandrau University of Antioquia4 aut |
700 | 1 | a Dow, Courtneyu Centre for Research in Epidemiology and Population Health (CESP),Stabilite genetique et oncogenese,University of Paris-Saclay4 aut |
700 | 1 | a Dorronsoro, Mirenu Public Health Division of Gipuzkoa4 aut |
700 | 1 | a Dinesen, Pia T.u Aalborg University4 aut |
700 | 1 | a Fagherazzi, Guyu University of Paris-Saclay,Stabilite genetique et oncogenese,Centre for Research in Epidemiology and Population Health (CESP)4 aut |
700 | 1 | a Franks, Paul W.u Umeå University,Lunds universitet,Umeå universitet,Medicin,Lund University, Malmö, Sweden,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-plf |
700 | 1 | a Feskens, Edith J. M.u Wageningen University4 aut |
700 | 1 | a Kühn, Tilmanu German Cancer Research Centre4 aut |
700 | 1 | a Katzke, Verena Andreau German Cancer Research Centre4 aut |
700 | 1 | a Key, Timothy J.u University of Oxford4 aut |
700 | 1 | a Khaw, Kay-Teeu University of Cambridge4 aut |
700 | 1 | a de Magistris, Maria Santucciu University of Naples Federico II4 aut |
700 | 1 | a Romana Mancini, Francescau University of Paris-Saclay,Stabilite genetique et oncogenese,Centre for Research in Epidemiology and Population Health (CESP)4 aut |
700 | 1 | a Molina-Portillo, Elenau CIBER Epidemiology and Public Health (CIBERESP),University of Granada4 aut |
700 | 1 | a Nilsson, Peter M.u Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-pni |
700 | 1 | a Olsen, Anjau Danish Cancer Society4 aut |
700 | 1 | a Overvad, Kimu Aarhus University,Aalborg University4 aut |
700 | 1 | a Palli, Domenicou Cancer Research and Prevention Institute (ISPO)4 aut |
700 | 1 | a Ramón Quirós, Joseu Public Health Directorate4 aut |
700 | 1 | a Rolandsson, Olovu Umeå University,Umeå universitet,Allmänmedicin4 aut0 (Swepub:umu)olro0005 |
700 | 1 | a Ricceri, Fulviou Citta' della Salute e della Scienza Hospital-University of Turin4 aut |
700 | 1 | a Spijkerman, Annemieke M. W.u National Institute for Public Health and the Environment (RIVM)4 aut |
700 | 1 | a Slimani, Nadiau International Agency for Research on Cancer, World Health Organization4 aut |
700 | 1 | a Tagliabue, Giovannau Istituto Nazionale dei Tumori4 aut |
700 | 1 | a Tjonneland, Anneu Danish Cancer Society4 aut |
700 | 1 | a Tumino, Rosariou Civic and M.P Arezzo Hospital4 aut |
700 | 1 | a van der Schouw, Yvonne T.u University Medical Center Utrecht4 aut |
700 | 1 | a Langenberg, Claudiau University of Cambridge4 aut |
700 | 1 | a Riboli, Eliou Imperial College London4 aut |
700 | 1 | a Forouhi, Nita G.u University of Cambridge4 aut |
700 | 1 | a Wareham, Nicholas J.u University of Cambridge4 aut |
710 | 2 | a University of Cambridgeb MRC Human Nutrition Research4 org |
773 | 0 | t BMC Medicined : BioMed Centralg 15q 15x 1741-7015 |
856 | 4 | u https://doi.org/10.1186/s12916-017-0968-4y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1162525/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://bmcmedicine.biomedcentral.com/track/pdf/10.1186/s12916-017-0968-4 |
856 | 4 | u http://dx.doi.org/10.1186/s12916-017-0968-4x freey FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-142454 |
856 | 4 8 | u https://doi.org/10.1186/s12916-017-0968-4 |
856 | 4 8 | u https://lup.lub.lu.se/record/8803677f-9b52-4741-817e-d6716d469233 |
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