Sökning: onr:"swepub:oai:DiVA.org:umu-14259" >
Tumor size, vascula...
Tumor size, vascular density and proliferation as prognostic markers in GS 6 and GS 7 prostate tumors in patients with long follow-up and non-curative treatment
-
- Josefsson, Andreas (författare)
- Umeå universitet,Patologi
-
- Wikström, Pernilla (författare)
- Umeå universitet,Patologi
-
Granfors, Torvald (författare)
-
visa fler...
-
- Egevad, Lars (författare)
- Karolinska Institutet
-
Karlberg, Lars (författare)
-
- Stattin, Pär (författare)
- Umeå universitet,Urologi och andrologi
-
- Bergh, Anders (författare)
- Umeå universitet,Patologi
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2005
- 2005
- Engelska.
-
Ingår i: European Urology. - : Elsevier BV. - 0302-2838 .- 1873-7560. ; 48:4, s. 577-583
- Relaterad länk:
-
http://www.ncbi.nlm....
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Objectives: To investigate the prognostic value of potential markers in localized, Gleason score 6 and 7 prostate cancer (PC). Methods: From a consecutive series of men with PC diagnosed at transurethral resection (1975-1990),. specimens from 132 patients without metastases, with Gleason score (GS) 6 (n = 80) or 7 (n = 52) tumors followed with watchful waiting were examined. The fraction of resected prostate tissue containing cancer, the micro-vessel density (v.d.) when stained for endoglin or von Willebrand factor (vWf), and the percentage of Ki-67 labeled tumor cells were measured using immunohistochemistry. Results: High levels of vWf v.d., endoglin v.d., and percent cancer of the TURP specimen were significantly associated with short cancer-specific survival in Kaplan-Meier analysis of all patients with GS 6 and 7 tumors. Interestingly, a combined estimate of percent cancer and vWF v.d. could be used to identify a large subset (50%) of GS 6 tumors with only a 2.5% risk of PC death within 15 years. None of the tested markers gave independent prognostic information for the GS 7 tumors. Conclusions: Estimates of tumor size and vascular density may identify a large proportion of non-aggressive GS 6, but not GS 7, tumors.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- Age Factors
- Aged
- Aged; 80 and over
- Antigens; CD/metabolism
- Follow-Up Studies
- Humans
- Immunohistochemistry
- Ki-67 Antigen/metabolism
- Male
- Middle Aged
- Neoplasm Staging
- Neovascularization; Pathologic/blood/surgery
- Predictive Value of Tests
- Prognosis
- Proportional Hazards Models
- Prostate/*blood supply
- Prostatic Neoplasms/blood/blood supply/*pathology/surgery
- Receptors; Cell Surface/metabolism
- Risk Factors
- Severity of Illness Index
- Survival Analysis
- Time Factors
- Transurethral Resection of Prostate
- Tumor Burden
- Tumor Markers; Biological/*blood
- von Willebrand Factor/metabolism
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas