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Long noncoding RNA ...
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Wu, CuiyanSchool of Public Health, Health Science Center of Xi'an Jiaotong University; Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission of the People's Republic of China, Xi'an, P.R. China
(författare)
Long noncoding RNA expression profile reveals lncRNAs signature associated with extracellular matrix degradation in kashin-beck disease
- Artikel/kapitelEngelska2017
Förlag, utgivningsår, omfång ...
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2017-12-14
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Nature Publishing Group,2017
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electronicrdacarrier
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LIBRIS-ID:oai:DiVA.org:umu-143104
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-143104URI
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https://doi.org/10.1038/s41598-017-17875-0DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Kashin-Beck disease (KBD) is a deformative, endemic osteochondropathy involving degeneration and necrosis of growth plates and articular cartilage. The pathogenesis of KBD is related to gene expression and regulation mechanisms, but long noncoding RNAs (lncRNAs) in KBD have not been investigated. In this study, we identified 316 up-regulated and 631 down-regulated lncRNAs (≥ 2-fold change) in KBD chondrocytes using microarray analysis, of which more than three-quarters were intergenic lncRNAs and antisense lncRNAs. We also identified 232 up-regulated and 427 down-regulated mRNAs (≥ 2-fold change). A lncRNA-mRNA correlation analysis combined 343 lncRNAs and 292 mRNAs to form 509 coding-noncoding gene co-expression networks (CNC networks). Eleven lncRNAs were predicted to have cis-regulated target genes, including NAV2 (neuron navigator 2), TOX (thymocyte selection-associated high mobility group box), LAMA4 (laminin, alpha 4), and DEPTOR (DEP domain containing mTOR-interacting protein). The differentially expressed mRNAs in KBD significantly contribute to biological events associated with the extracellular matrix. Meanwhile, 34 mRNAs and 55 co-expressed lncRNAs constituted a network that influences the extracellular matrix. In the network, FBLN1 and LAMA 4 were the core genes with the highest significance. These novel findings indicate that lncRNAs may play a role in extracellular matrix destruction in KBD.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Liu, HuanSchool of Public Health, Health Science Center of Xi'an Jiaotong University; Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission of the People's Republic of China, Xi'an, P.R. China
(författare)
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Zhang, Feng'eSchool of Public Health, Health Science Center of Xi'an Jiaotong University; Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission of the People's Republic of China, Xi'an, P.R. China
(författare)
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Shao, WanzhenSchool of Public Health, Health Science Center of Xi'an Jiaotong University; Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission of the People's Republic of China, Xi'an, P.R. China
(författare)
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Yang, LeiSchool of Public Health, Health Science Center of Xi'an Jiaotong University; Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission of the People's Republic of China, Xi'an, P.R. China
(författare)
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Ning, YujieSchool of Public Health, Health Science Center of Xi'an Jiaotong University; Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission of the People's Republic of China, Xi'an, P.R. China
(författare)
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Wang, SenSchool of Public Health, Health Science Center of Xi'an Jiaotong University; Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission of the People's Republic of China, Xi'an, P.R. China
(författare)
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Zhao, GuanghuiDepartment of Knee Joint, Xi'an Hong Hui Hospital, Xi'an, P.R. China
(författare)
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Lee, Byeong JaeInstitute of Molecular Biology and Genetics, School of Biological Sciences, Seoul National University, Seoul, Korea
(författare)
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Lammi, Mikko,1961-Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Chondrogenic and Osteogenic Differentiation Group(Swepub:umu)mila0077
(författare)
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Guo, Xiong
(författare)
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School of Public Health, Health Science Center of Xi'an Jiaotong University; Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission of the People's Republic of China, Xi'an, P.R. ChinaDepartment of Knee Joint, Xi'an Hong Hui Hospital, Xi'an, P.R. China
(creator_code:org_t)
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Ingår i:Scientific Reports: Nature Publishing Group72045-2322
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Wu, Cuiyan
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Liu, Huan
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Zhang, Feng'e
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Shao, Wanzhen
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Yang, Lei
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Ning, Yujie
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Wang, Sen
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Zhao, Guanghui
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Lee, Byeong Jae
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Lammi, Mikko, 19 ...
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Guo, Xiong
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