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- Bråbäck, LennartUmeå universitet,Yrkes- och miljömedicin (författare)
Childhood asthma and smoking exposures before conception - a three-generational cohort study.
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
- 2018-04-15
- Wiley,2018
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:umu-145533
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-145533URI
- https://doi.org/10.1111/pai.12883DOI
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- Språk:engelska
- Sammanfattning på:engelska
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- BACKGROUND: Some human and animal studies have recently shown that maternal grandmother's smoking during pregnancy increases the risk of asthma in the grandchildren. We have investigated whether sex of the exposed parent and/or grandchild modifies the association between grandmaternal smoking and grandchild asthma.METHODS: We formed a cohort study based on linkage of national registries with prospectively collected data over three generations. Smoking habits in early pregnancy were registered since 1982 and purchases of prescribed medication since 2005. In all, 10329 children born since 2005 had information on maternal and grandmaternal smoking on both sides and were followed from birth up to 6 years of age. Ages when medication was purchased were used to classify the cohort into never, early transient (0-3 years), early persistent (0-3 and 4-6 years) and late-onset (4-6 years) phenotypes of childhood asthma.RESULTS: Maternal grandmother's smoking was associated with an increased odds of early persistent asthma after adjustment for maternal smoking and other confounders (odds ratio 1.29, 95% confidence interval 1.10-1.51). Grandchild sex did not modify the association. Paternal grandmother's smoking was not associated with any of the asthma phenotypes.CONCLUSION: Maternal but not paternal exposure to nicotine before conception was related to an increased risk of early persistent childhood asthma, but not other asthma phenotypes. Our findings are possibly consistent with a sex specific mode of epigenetic transfer.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Lungmedicin och allergi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Respiratory Medicine and Allergy hsv//eng
- childhood asthma
- grandmother
- multigenerational study
- pregnancy
- tobacco smoke
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Lowe, Adrian JUmeå universitet,Yrkes- och miljömedicin,Allergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Australia. Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.(Swepub:umu)load0001 (författare)
- Lodge, Caroline JUmeå universitet,Yrkes- och miljömedicin,Allergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Australia. Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.(Swepub:umu)calo0020 (författare)
- Dharmage, Shyamali CAllergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Australia. Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia. (författare)
- Olsson, DavidUmeå universitet,Yrkes- och miljömedicin(Swepub:umu)daol0005 (författare)
- Forsberg, BertilUmeå universitet,Yrkes- och miljömedicin(Swepub:umu)befo0001 (författare)
- Umeå universitetYrkes- och miljömedicin (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Pediatric Allergy and Immunology: Wiley29:4, s. 361-3680905-61571399-3038
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- Pediatric Allergy and Immunology (Sök värdpublikationen i LIBRIS)
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