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Past and current ca...
Past and current cause-specific mortality in Eisenmenger syndrome.
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- Hjortshøj, Cristel M Sørensen (författare)
- Copenhagen University Hospital
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- Kempny, Aleksander (författare)
- Royal Brompton Hospital
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- Jensen, Annette Schophuus (författare)
- Copenhagen University Hospital
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- Sørensen, Keld (författare)
- Aalborg University
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- Nagy, Edit (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Dellborg, Mikael (författare)
- Sahlgrenska Academy
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- Johansson, Bengt (författare)
- Norrland University Hospital
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- Rudiene, Virginija (författare)
- Vilnius University
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- Hong, Gu (författare)
- Capital University of Medical Sciences
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- Opotowsky, Alexander R (författare)
- Brigham and Women's Hospital / Harvard Medical School
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- Budts, Werner (författare)
- University Hospitals Leuven
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- Mulder, Barbara J (författare)
- Academic Medical Center of University of Amsterdam (AMC)
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- Tomkiewicz-Pajak, Lidia (författare)
- Jagiellonian University
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- D'Alto, Michele (författare)
- University of Campania Luigi Vanvitelli
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- Prokšelj, Katja (författare)
- University Medical Centre Ljubljana
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- Diller, Gerhard-Paul (författare)
- Royal Brompton Hospital
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- Dimopoulos, Konstantinos (författare)
- Royal Brompton Hospital
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- Estensen, Mette-Elise (författare)
- Norwegian Radium Hospital
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- Holmstrøm, Henrik (författare)
- Norwegian Radium Hospital
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- Turanlahti, Maila (författare)
- Helsinki University Central Hospital
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- Thilén, Ulf (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Gatzoulis, Michael A (författare)
- Royal Brompton Hospital
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- Søndergaard, Lars (författare)
- Copenhagen University Hospital
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(creator_code:org_t)
- 2017-04-18
- 2017
- Engelska.
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Ingår i: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 38:26, s. 2060-2067
- Relaterad länk:
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https://academic.oup...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Aims: Eisenmenger syndrome (ES) is associated with considerable morbidity and mortality. Therapeutic strategies have changed during the 2000s in conjunction with an emphasis on specialist follow-up. The aim of this study was to determine the cause-specific mortality in ES and evaluate any relevant changes between 1977 and 2015.Methods and results: This is a retrospective, descriptive multicentre study. A total of 1546 patients (mean age 38.7 ± 15.4 years; 36% male) from 13 countries were included. Cause-specific mortality was examined before and after July 2006, 'early' and 'late', respectively. Over a median follow-up of 6.1 years (interquartile range 2.1-21.5 years) 558 deaths were recorded; cause-specific mortality was identified in 411 (74%) cases. Leading causes of death were heart failure (34%), infection (26%), sudden cardiac death (10%), thromboembolism (8%), haemorrhage (7%), and peri-procedural (7%). Heart failure deaths increased in the 'late' relative to the 'early' era (P = 0.032), whereas death from thromboembolic events and death in relation to cardiac and non-cardiac procedures decreased (P = 0.014, P = 0.014, P = 0.004, respectively). There was an increase in longevity in the 'late' vs. 'early' era (median survival 52.3 vs. 35.2 years, P < 0.001).Conclusion: The study shows that despite changes in therapy, care, and follow-up of ES in tertiary care centres, all-cause mortality including cardiac remains high. Patients from the 'late' era, however, die later and from chronic rather than acute cardiac causes, primarily heart failure, whereas peri-procedural and deaths due to haemoptysis have become less common. Lifelong vigilance in tertiary centres and further research for ES are clearly needed.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Cause of death
- Eisenmenger syndrome
- Heart failure
- Mortality
- Pulmonary arterial hypertension
- kardiologi
- Cardiology
- Cause of death
- Eisenmenger syndrome
- Heart failure
- Mortality
- Pulmonary arterial hypertension
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Hjortshøj, Crist ...
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Kempny, Aleksand ...
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Jensen, Annette ...
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Sørensen, Keld
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Nagy, Edit
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Dellborg, Mikael
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Johansson, Bengt
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Rudiene, Virgini ...
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Hong, Gu
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Opotowsky, Alexa ...
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Budts, Werner
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Mulder, Barbara ...
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Tomkiewicz-Pajak ...
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D'Alto, Michele
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Prokšelj, Katja
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Diller, Gerhard- ...
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Dimopoulos, Kons ...
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Estensen, Mette- ...
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Holmstrøm, Henri ...
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Turanlahti, Mail ...
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Thilén, Ulf
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Gatzoulis, Micha ...
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Søndergaard, Lar ...
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European Heart J ...
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