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Sökning: onr:"swepub:oai:DiVA.org:umu-147482" > Interaction of Diet...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007686naa a2200841 4500
001oai:DiVA.org:umu-147482
003SwePub
008180507s2018 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:e45f2fbc-593b-4133-93a3-c33227a5b398
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1474822 URI
0247 a https://doi.org/10.2337/dc17-10802 DOI
0247 a https://lup.lub.lu.se/record/e45f2fbc-593b-4133-93a3-c33227a5b3982 URI
040 a (SwePub)umud (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Meidtner, Karinau German Institute of Human Nutrition,German Center for Diabetes Research4 aut
2451 0a Interaction of Dietary and Genetic Factors Influencing Body Iron Status and Risk of Type 2 Diabetes Within the EPIC-InterAct Study
264 c 2017-11-22
264 1b American Diabetes Association,c 2018
338 a print2 rdacarrier
520 a OBJECTIVE: Meat intake has been consistently shown to be positively associated with incident type 2 diabetes. Part of that association may be mediated by body iron status, which is influenced by genetic factors. We aimed to test for interactions of genetic and dietary factors influencing body iron status in relation to the risk of incident type 2 diabetes.RESEARCH DESIGN AND METHODS: The case-cohort comprised 9,347 case subjects and 12,301 subcohort participants from eight European countries. Single nucleotide polymorphisms (SNPs) were selected from genome-wide association studies on iron status biomarkers and candidate gene studies. A ferritin-related gene score was constructed. Multiplicative and additive interactions of heme iron and SNPs as well as the gene score were evaluated using Cox proportional hazards regression.RESULTS: Higher heme iron intake (per 1 SD) was associated with higher ferritin levels (β = 0.113 [95% CI 0.082; 0.144]), but not with transferrin (−0.019 [−0.043; 0.006]) or transferrin saturation (0.016 [−0.006; 0.037]). Five SNPs located in four genes (rs1799945 [HFE H63D], rs1800562 [HFE C282Y], rs236918 [PCK7], rs744653 [SLC40A1], and rs855791 [TMPRSS6V736A]) were associated with ferritin. We did not detect an interaction of heme iron and the gene score on the risk of diabetes in the overall study population (Padd = 0.16, Pmult = 0.21) but did detect a trend toward a negative interaction in men (Padd = 0.04, Pmult = 0.03).CONCLUSIONS: We found no convincing evidence that the interplay of dietary and genetic factors related to body iron status associates with type 2 diabetes risk above the level expected from the sum or product of the two individual exposures.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
7001 a Podmore, Clarau University of Cambridge4 aut
7001 a Kroger, Janineu German Institute of Human Nutrition4 aut
7001 a van der Schouw, Yvonne T.u University Medical Center Utrecht4 aut
7001 a Bendinelli, Benedettau Cancer Research and Prevention Institute (ISPO),German Center for Diabetes Research,German Institute of Human Nutrition4 aut
7001 a Agnoli, Claudiau Istituto Nazionale dei Tumori4 aut
7001 a Arriola, Larraitzu Biodonostia Health Research Institute,Public Health Division of Gipuzkoa,CIBER Epidemiology and Public Health (CIBERESP)4 aut
7001 a Barricarte, Aureliou Navarre Public Health Institute (ISPN),CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)4 aut
7001 a Boeing, Heineru German Institute of Human Nutrition4 aut
7001 a Cross, Amanda J.u Imperial College London,International Agency for Research on Cancer, World Health Organization4 aut
7001 a Dow, Courtneyu Centre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay,Institut Gustave Roussy4 aut
7001 a Ekblom, Kimu Umeå University,Umeå universitet,Klinisk kemi4 aut0 (Swepub:umu)kimekm00
7001 a Fagherazzi, Guyu Institut Gustave Roussy,University of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP)4 aut
7001 a Franks, Paul W.u Umeå University,Umeå universitet,Avdelningen för medicin,Department of Clinical Sciences, Lund University, Malmö, Sweden4 aut0 (Swepub:lu)med-plf
7001 a Gunter, Marc J.u International Agency for Research on Cancer, World Health Organization4 aut
7001 a Huerta, Jose Mariau Biodonostia Health Research Institute,Murcia Regional Health Council4 aut
7001 a Jakszyn, Paulau Ramon Llull University,Catalan Institute of Oncology4 aut
7001 a Jenab, Mazda4 aut
7001 a Katzke, Verena A.u German Cancer Research Centre4 aut
7001 a Key, Timothy J.u University of Oxford4 aut
7001 a Khaw, Kay Teeu University of Cambridge4 aut
7001 a Kuhn, Tilmanu German Cancer Research Centre4 aut
7001 a Kyro, Cecilieu Danish Cancer Society4 aut
7001 a Mancini, Francesca Romanau Institut Gustave Roussy,University of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP)4 aut
7001 a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome
7001 a Nilsson, Peter M.u Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-pni
7001 a Overvad, Kimu Aarhus University,Aalborg University4 aut
7001 a Palli, Domenicou Cancer Research and Prevention Institute (ISPO)4 aut
7001 a Panico, Salvatoreu University of Naples Federico II4 aut
7001 a Quiros, J. Ramonu Public Health Directorate4 aut
7001 a Rodriguez-Barranco, Miguelu CIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP)4 aut
7001 a Sacerdote, Carlottau Citta' della Salute e della Scienza Hospital-University of Turin,Human Genetics Foundation (HuGeF)4 aut
7001 a Sluijs, Ivonneu University Medical Center Utrecht4 aut
7001 a Stepien, Magdalenau International Agency for Research on Cancer, World Health Organization4 aut
7001 a Tjonneland, Anneu Danish Cancer Society4 aut
7001 a Tumino, Rosariou L’ Associazione Iblea per la Ricerca Epidemiologica (A.I.R.E.),Civic and M.P Arezzo Hospital4 aut
7001 a Forouhi, Nita G.u University of Cambridge4 aut
7001 a Sharp, Stephen J.u University of Cambridge4 aut
7001 a Langenberg, Claudiau University of Cambridge4 aut
7001 a Schulze, Matthias B.4 aut
7001 a Riboli, Eliou Imperial College London4 aut
7001 a Wareham, Nicholas J.u University of Cambridge4 aut
7102 a German Institute of Human Nutritionb German Center for Diabetes Research4 org
7730 t Diabetes Cared : American Diabetes Associationg 41:2, s. 277-285q 41:2<277-285x 0149-5992x 1935-5548
8564 u https://care.diabetesjournals.org/content/diacare/41/2/277.full.pdf
8564 u http://dx.doi.org/10.2337/dc17-1080y FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-147482
8564 8u https://doi.org/10.2337/dc17-1080
8564 8u https://lup.lub.lu.se/record/e45f2fbc-593b-4133-93a3-c33227a5b398

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